The role of long non-coding RNA GAS5 in cancers

Jiali Ji; Xiaolan Dai; Sai Ching Jim Yeung; Xuexin He

doi:10.2147/CMAR.S189052

The role of long non-coding RNA GAS5 in cancers

Jiali Ji, Xiaolan Dai, Sai Ching Jim Yeung, Xuexin He

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

Long non-coding RNAs (lncRNAs) have shown potential as a biomarker in the diagnosis and prognosis in multiple cancers. LncRNAs are dysregulated in various cancers, playing either oncogenic or tumor suppressive roles. Emerging evidences have proved that the growth arrest-specific 5 (GAS5) lncRNA can function as a tumor suppressor in several cancers. LncRNA GAS5 is downregulated in many types of cancer, regulating cellular processes such as cell proliferation, apoptosis and invasion. The low level of GAS5 expression often elevates capacity of proliferation and predicts poorer prognosis in some cancers. This review aims to summarize the recent published literature on the biogenesis, regulation mechanism and function of GAS5 in different types of cancers and explore its potential for cancer diagnosis, prognosis and treatment.

Original language	English (US)
Pages (from-to)	2729-2737
Number of pages	9
Journal	Cancer Management and Research
Volume	11
DOIs	https://doi.org/10.2147/CMAR.S189052
State	Published - 2019

Keywords

GAS5
LncRNA
Tumor
Tumor suppressor

ASJC Scopus subject areas

Oncology

Access to Document

10.2147/CMAR.S189052

Cite this

@article{646f15c2ae764ad38d4951d485641423,

title = "The role of long non-coding RNA GAS5 in cancers",

abstract = "Long non-coding RNAs (lncRNAs) have shown potential as a biomarker in the diagnosis and prognosis in multiple cancers. LncRNAs are dysregulated in various cancers, playing either oncogenic or tumor suppressive roles. Emerging evidences have proved that the growth arrest-specific 5 (GAS5) lncRNA can function as a tumor suppressor in several cancers. LncRNA GAS5 is downregulated in many types of cancer, regulating cellular processes such as cell proliferation, apoptosis and invasion. The low level of GAS5 expression often elevates capacity of proliferation and predicts poorer prognosis in some cancers. This review aims to summarize the recent published literature on the biogenesis, regulation mechanism and function of GAS5 in different types of cancers and explore its potential for cancer diagnosis, prognosis and treatment.",

keywords = "GAS5, LncRNA, Tumor, Tumor suppressor",

author = "Jiali Ji and Xiaolan Dai and Yeung, {Sai Ching Jim} and Xuexin He",

note = "Funding Information: This work was supported by a grant from the Ph.D. Programs Foundation of Ministry of Education of China (No. 20120101120132) Publisher Copyright: {\textcopyright} 2019 Ji et al.",

year = "2019",

doi = "10.2147/CMAR.S189052",

language = "English (US)",

volume = "11",

pages = "2729--2737",

journal = "Cancer Management and Research",

issn = "1179-1322",

publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - The role of long non-coding RNA GAS5 in cancers

AU - Ji, Jiali

AU - Dai, Xiaolan

AU - Yeung, Sai Ching Jim

AU - He, Xuexin

PY - 2019

Y1 - 2019

N2 - Long non-coding RNAs (lncRNAs) have shown potential as a biomarker in the diagnosis and prognosis in multiple cancers. LncRNAs are dysregulated in various cancers, playing either oncogenic or tumor suppressive roles. Emerging evidences have proved that the growth arrest-specific 5 (GAS5) lncRNA can function as a tumor suppressor in several cancers. LncRNA GAS5 is downregulated in many types of cancer, regulating cellular processes such as cell proliferation, apoptosis and invasion. The low level of GAS5 expression often elevates capacity of proliferation and predicts poorer prognosis in some cancers. This review aims to summarize the recent published literature on the biogenesis, regulation mechanism and function of GAS5 in different types of cancers and explore its potential for cancer diagnosis, prognosis and treatment.

AB - Long non-coding RNAs (lncRNAs) have shown potential as a biomarker in the diagnosis and prognosis in multiple cancers. LncRNAs are dysregulated in various cancers, playing either oncogenic or tumor suppressive roles. Emerging evidences have proved that the growth arrest-specific 5 (GAS5) lncRNA can function as a tumor suppressor in several cancers. LncRNA GAS5 is downregulated in many types of cancer, regulating cellular processes such as cell proliferation, apoptosis and invasion. The low level of GAS5 expression often elevates capacity of proliferation and predicts poorer prognosis in some cancers. This review aims to summarize the recent published literature on the biogenesis, regulation mechanism and function of GAS5 in different types of cancers and explore its potential for cancer diagnosis, prognosis and treatment.

KW - GAS5

KW - LncRNA

KW - Tumor

KW - Tumor suppressor

UR - http://www.scopus.com/inward/record.url?scp=85065057995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065057995&partnerID=8YFLogxK

U2 - 10.2147/CMAR.S189052

DO - 10.2147/CMAR.S189052

M3 - Review article

C2 - 31114330

AN - SCOPUS:85065057995

SN - 1179-1322

VL - 11

SP - 2729

EP - 2737

JO - Cancer Management and Research

JF - Cancer Management and Research

ER -

The role of long non-coding RNA GAS5 in cancers

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this