The role of microRNA in esophageal squamous cell carcinoma

Kazuto Harada; Yoshifumi Baba; Takatsugu Ishimoto; Hironobu Shigaki; Keisuke Kosumi; Naoya Yoshida; Masayuki Watanabe; Hideo Baba

doi:10.1007/s00535-016-1161-9

The role of microRNA in esophageal squamous cell carcinoma

Kazuto Harada, Yoshifumi Baba, Takatsugu Ishimoto, Hironobu Shigaki, Keisuke Kosumi, Naoya Yoshida, Masayuki Watanabe, Hideo Baba

Cancer Prevention Training Program

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

MicroRNAs (miRNA) are 22-nucleotide non-coding RNAs that post-transcriptionally regulate gene expression by base pairing to partially complementary sequences in the 3′-untranslated region of their target messenger RNA. Altered miRNA expression also changes the expression of oncogenes and tumor suppressors, affecting the proliferation, apoptosis, motility and invasibility of gastrointestinal cancer cells, including the cells of esophageal squamous cell carcinoma (ESCC). It has been suggested that various miRNA expression profiles may provide useful biomarkers and therapeutic targets, but to date few studies have been published on the role of miRNA in ESCC. In this review we summarize the identification and characterization of miRNAs involved in ESCC and discuss their potential as biomarkers and therapeutic targets.

Original language	English (US)
Pages (from-to)	520-530
Number of pages	11
Journal	Journal of gastroenterology
Volume	51
Issue number	6
DOIs	https://doi.org/10.1007/s00535-016-1161-9
State	Published - Jun 1 2016

Keywords

Biomarkers
Esophageal squamous cell carcinoma
MicroRNA
Review
Therapeutic targets

ASJC Scopus subject areas

Gastroenterology

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10.1007/s00535-016-1161-9

Cite this

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title = "The role of microRNA in esophageal squamous cell carcinoma",

abstract = "MicroRNAs (miRNA) are 22-nucleotide non-coding RNAs that post-transcriptionally regulate gene expression by base pairing to partially complementary sequences in the 3′-untranslated region of their target messenger RNA. Altered miRNA expression also changes the expression of oncogenes and tumor suppressors, affecting the proliferation, apoptosis, motility and invasibility of gastrointestinal cancer cells, including the cells of esophageal squamous cell carcinoma (ESCC). It has been suggested that various miRNA expression profiles may provide useful biomarkers and therapeutic targets, but to date few studies have been published on the role of miRNA in ESCC. In this review we summarize the identification and characterization of miRNAs involved in ESCC and discuss their potential as biomarkers and therapeutic targets.",

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AU - Harada, Kazuto

AU - Baba, Yoshifumi

AU - Ishimoto, Takatsugu

AU - Shigaki, Hironobu

AU - Kosumi, Keisuke

AU - Yoshida, Naoya

AU - Watanabe, Masayuki

AU - Baba, Hideo

PY - 2016/6/1

Y1 - 2016/6/1

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AB - MicroRNAs (miRNA) are 22-nucleotide non-coding RNAs that post-transcriptionally regulate gene expression by base pairing to partially complementary sequences in the 3′-untranslated region of their target messenger RNA. Altered miRNA expression also changes the expression of oncogenes and tumor suppressors, affecting the proliferation, apoptosis, motility and invasibility of gastrointestinal cancer cells, including the cells of esophageal squamous cell carcinoma (ESCC). It has been suggested that various miRNA expression profiles may provide useful biomarkers and therapeutic targets, but to date few studies have been published on the role of miRNA in ESCC. In this review we summarize the identification and characterization of miRNAs involved in ESCC and discuss their potential as biomarkers and therapeutic targets.

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KW - Therapeutic targets

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The role of microRNA in esophageal squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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