The role of microRNA in human leukemia: A review

S. Yendamuri; G. A. Calin

doi:10.1038/leu.2008.382

The role of microRNA in human leukemia: A review

S. Yendamuri, G. A. Calin

Graduate School of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

MicroRNAs (miRNAs or miRs) are 18-22-nucleotide non-coding RNAs that have emerged as a new paradigm of epigenetic regulation in both normal development and cellular function, and in the pathogenesis of human disease including cancer. This review summarizes the current literature of mechanism of gene regulation by miRNA and their role in hematopoiesis and leukemogenesis. An understanding of these processes suggests further avenues for research to understand gene regulation and miRNA-based therapeutic approaches.

Original language	English (US)
Pages (from-to)	1257-1263
Number of pages	7
Journal	Leukemia
Volume	23
Issue number	7
DOIs	https://doi.org/10.1038/leu.2008.382
State	Published - 2009

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.1038/leu.2008.382

Cite this

@article{7592faa074564f07b539e732c6c13e20,

title = "The role of microRNA in human leukemia: A review",

abstract = "MicroRNAs (miRNAs or miRs) are 18-22-nucleotide non-coding RNAs that have emerged as a new paradigm of epigenetic regulation in both normal development and cellular function, and in the pathogenesis of human disease including cancer. This review summarizes the current literature of mechanism of gene regulation by miRNA and their role in hematopoiesis and leukemogenesis. An understanding of these processes suggests further avenues for research to understand gene regulation and miRNA-based therapeutic approaches.",

author = "S. Yendamuri and Calin, {G. A.}",

note = "Funding Information: Dr Calin is supported as a Fellow of The University of Texas MD Anderson Research Trust, as a Fellow of University of Texas System Regents Research Scholar and as a Ladjevardian Regents Research Scholar Fund. This study was also funded by an Institutional Research Grant and by a CCSG Award to George A Calin.",

year = "2009",

doi = "10.1038/leu.2008.382",

language = "English (US)",

volume = "23",

pages = "1257--1263",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "7",

}

TY - JOUR

T1 - The role of microRNA in human leukemia

T2 - A review

AU - Yendamuri, S.

AU - Calin, G. A.

N1 - Funding Information: Dr Calin is supported as a Fellow of The University of Texas MD Anderson Research Trust, as a Fellow of University of Texas System Regents Research Scholar and as a Ladjevardian Regents Research Scholar Fund. This study was also funded by an Institutional Research Grant and by a CCSG Award to George A Calin.

PY - 2009

Y1 - 2009

N2 - MicroRNAs (miRNAs or miRs) are 18-22-nucleotide non-coding RNAs that have emerged as a new paradigm of epigenetic regulation in both normal development and cellular function, and in the pathogenesis of human disease including cancer. This review summarizes the current literature of mechanism of gene regulation by miRNA and their role in hematopoiesis and leukemogenesis. An understanding of these processes suggests further avenues for research to understand gene regulation and miRNA-based therapeutic approaches.

AB - MicroRNAs (miRNAs or miRs) are 18-22-nucleotide non-coding RNAs that have emerged as a new paradigm of epigenetic regulation in both normal development and cellular function, and in the pathogenesis of human disease including cancer. This review summarizes the current literature of mechanism of gene regulation by miRNA and their role in hematopoiesis and leukemogenesis. An understanding of these processes suggests further avenues for research to understand gene regulation and miRNA-based therapeutic approaches.

UR - http://www.scopus.com/inward/record.url?scp=67650912359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650912359&partnerID=8YFLogxK

U2 - 10.1038/leu.2008.382

DO - 10.1038/leu.2008.382

M3 - Review article

C2 - 19148134

AN - SCOPUS:67650912359

SN - 0887-6924

VL - 23

SP - 1257

EP - 1263

JO - Leukemia

JF - Leukemia

IS - 7

ER -

The role of microRNA in human leukemia: A review

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this