The role of neuropeptide processing enzymes in endocrine (Prostate) cancer: EC3.4.24.15 (EP24.15)

Todd A. Swanson; Sandra I. Kim; Michael Myers; Amanda Pabon; Keith D. Philibert; Mina Wang; Marc J. Glucksman

doi:10.2174/0929866043406607

The role of neuropeptide processing enzymes in endocrine (Prostate) cancer: EC3.4.24.15 (EP24.15)

Todd A. Swanson, Sandra I. Kim, Michael Myers, Amanda Pabon, Keith D. Philibert, Mina Wang, Marc J. Glucksman

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

The zinc metalloendopeptidase EC3.4.24.15 [EP24.15, thimet oligopeptidase], a neuropeptide processing enzyme, is central to the formation and degradation of many bioactive peptides in the neural proteome, and is highly expressed in normal prostate. EP24.15 actions are increased in androgen-dependent prostate cancer compared to androgen-independent; augmented by androgen treatment, and inhibited by clinical GnRH analogs. The "neural" prostate includes: neuropeptides, cognate receptors and processing enzymes regulating signaling of peptide-mediated neural inputs.

Original language	English (US)
Pages (from-to)	471-478
Number of pages	8
Journal	Protein and Peptide Letters
Volume	11
Issue number	5
DOIs	https://doi.org/10.2174/0929866043406607
State	Published - Oct 2004
Externally published	Yes

Keywords

Cancer
Endocrine
Metalloenzyme
Metallopeptidase
Neuropeptide
Prostate
Proteome

ASJC Scopus subject areas

Structural Biology
Biochemistry

Access to Document

10.2174/0929866043406607

Cite this

@article{2d34ea24df2e4dca9b89fa16451cae92,

title = "The role of neuropeptide processing enzymes in endocrine (Prostate) cancer: EC3.4.24.15 (EP24.15)",

abstract = "The zinc metalloendopeptidase EC3.4.24.15 [EP24.15, thimet oligopeptidase], a neuropeptide processing enzyme, is central to the formation and degradation of many bioactive peptides in the neural proteome, and is highly expressed in normal prostate. EP24.15 actions are increased in androgen-dependent prostate cancer compared to androgen-independent; augmented by androgen treatment, and inhibited by clinical GnRH analogs. The {"}neural{"} prostate includes: neuropeptides, cognate receptors and processing enzymes regulating signaling of peptide-mediated neural inputs.",

keywords = "Cancer, Endocrine, Metalloenzyme, Metallopeptidase, Neuropeptide, Prostate, Proteome",

author = "Swanson, {Todd A.} and Kim, {Sandra I.} and Michael Myers and Amanda Pabon and Philibert, {Keith D.} and Mina Wang and Glucksman, {Marc J.}",

year = "2004",

month = oct,

doi = "10.2174/0929866043406607",

language = "English (US)",

volume = "11",

pages = "471--478",

journal = "Protein and Peptide Letters",

issn = "0929-8665",

publisher = "Bentham Science Publishers B.V.",

number = "5",

}

TY - JOUR

T1 - The role of neuropeptide processing enzymes in endocrine (Prostate) cancer

T2 - EC3.4.24.15 (EP24.15)

AU - Swanson, Todd A.

AU - Kim, Sandra I.

AU - Myers, Michael

AU - Pabon, Amanda

AU - Philibert, Keith D.

AU - Wang, Mina

AU - Glucksman, Marc J.

PY - 2004/10

Y1 - 2004/10

N2 - The zinc metalloendopeptidase EC3.4.24.15 [EP24.15, thimet oligopeptidase], a neuropeptide processing enzyme, is central to the formation and degradation of many bioactive peptides in the neural proteome, and is highly expressed in normal prostate. EP24.15 actions are increased in androgen-dependent prostate cancer compared to androgen-independent; augmented by androgen treatment, and inhibited by clinical GnRH analogs. The "neural" prostate includes: neuropeptides, cognate receptors and processing enzymes regulating signaling of peptide-mediated neural inputs.

AB - The zinc metalloendopeptidase EC3.4.24.15 [EP24.15, thimet oligopeptidase], a neuropeptide processing enzyme, is central to the formation and degradation of many bioactive peptides in the neural proteome, and is highly expressed in normal prostate. EP24.15 actions are increased in androgen-dependent prostate cancer compared to androgen-independent; augmented by androgen treatment, and inhibited by clinical GnRH analogs. The "neural" prostate includes: neuropeptides, cognate receptors and processing enzymes regulating signaling of peptide-mediated neural inputs.

KW - Cancer

KW - Endocrine

KW - Metalloenzyme

KW - Metallopeptidase

KW - Neuropeptide

KW - Prostate

KW - Proteome

UR - http://www.scopus.com/inward/record.url?scp=4444227534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444227534&partnerID=8YFLogxK

U2 - 10.2174/0929866043406607

DO - 10.2174/0929866043406607

M3 - Review article

C2 - 15544568

AN - SCOPUS:4444227534

SN - 0929-8665

VL - 11

SP - 471

EP - 478

JO - Protein and Peptide Letters

JF - Protein and Peptide Letters

IS - 5

ER -

The role of neuropeptide processing enzymes in endocrine (Prostate) cancer: EC3.4.24.15 (EP24.15)

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this