Rol del gen SPARC en la capacidad tumorigenica de celulas de melanoma humano

M. Fernanda Ledda; Soraya Adris; Laura Bover; Alicia L. Bravo; Jose Mordoh; Osvaldo L. Podhajcer

Rol del gen SPARC en la capacidad tumorigenica de celulas de melanoma humano

Translated title of the contribution: The role of SPARC gene in the tumorigenic capacity of human melanoma cells

M. Fernanda Ledda, Soraya Adris, Laura Bover, Alicia L. Bravo, Jose Mordoh, Osvaldo L. Podhajcer

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Previous studies from our laboratory have demonstrated that human melanoma cell lines and tumors expressed high levels of the extracellular protein SPARC. In order to demonstrate its role in human melanoma progression, IIB-MEL-LES human melanoma cells were transfected with SPARC full length c-DNA in the antisense orientation. In vivo studies demonstrated that all the control mice injected with parental cells developed tumors, while none of the mice injected with cells obtained from three different clones with diminished levels of SPARC expression, developed tumors. These studies suggest that SPARC may play a key role in human melanoma progression.

Translated title of the contribution	The role of SPARC gene in the tumorigenic capacity of human melanoma cells
Original language	Spanish
Pages (from-to)	51-54
Number of pages	4
Journal	Medicina
Volume	56
Issue number	1
State	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Rol del gen SPARC en la capacidad tumorigenica de celulas de melanoma humano",

abstract = "Previous studies from our laboratory have demonstrated that human melanoma cell lines and tumors expressed high levels of the extracellular protein SPARC. In order to demonstrate its role in human melanoma progression, IIB-MEL-LES human melanoma cells were transfected with SPARC full length c-DNA in the antisense orientation. In vivo studies demonstrated that all the control mice injected with parental cells developed tumors, while none of the mice injected with cells obtained from three different clones with diminished levels of SPARC expression, developed tumors. These studies suggest that SPARC may play a key role in human melanoma progression.",

author = "Ledda, {M. Fernanda} and Soraya Adris and Laura Bover and Bravo, {Alicia L.} and Jose Mordoh and Podhajcer, {Osvaldo L.}",

year = "1996",

language = "Spanish",

volume = "56",

pages = "51--54",

journal = "Medicina",

issn = "0025-7680",

publisher = "Instituto de Investigaciones Medicas",

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TY - JOUR

T1 - Rol del gen SPARC en la capacidad tumorigenica de celulas de melanoma humano

AU - Ledda, M. Fernanda

AU - Adris, Soraya

AU - Bover, Laura

AU - Bravo, Alicia L.

AU - Mordoh, Jose

AU - Podhajcer, Osvaldo L.

PY - 1996

Y1 - 1996

N2 - Previous studies from our laboratory have demonstrated that human melanoma cell lines and tumors expressed high levels of the extracellular protein SPARC. In order to demonstrate its role in human melanoma progression, IIB-MEL-LES human melanoma cells were transfected with SPARC full length c-DNA in the antisense orientation. In vivo studies demonstrated that all the control mice injected with parental cells developed tumors, while none of the mice injected with cells obtained from three different clones with diminished levels of SPARC expression, developed tumors. These studies suggest that SPARC may play a key role in human melanoma progression.

AB - Previous studies from our laboratory have demonstrated that human melanoma cell lines and tumors expressed high levels of the extracellular protein SPARC. In order to demonstrate its role in human melanoma progression, IIB-MEL-LES human melanoma cells were transfected with SPARC full length c-DNA in the antisense orientation. In vivo studies demonstrated that all the control mice injected with parental cells developed tumors, while none of the mice injected with cells obtained from three different clones with diminished levels of SPARC expression, developed tumors. These studies suggest that SPARC may play a key role in human melanoma progression.

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M3 - Article

C2 - 8734932

AN - SCOPUS:3042980113

SN - 0025-7680

VL - 56

SP - 51

EP - 54

JO - Medicina

JF - Medicina

IS - 1

ER -

Rol del gen SPARC en la capacidad tumorigenica de celulas de melanoma humano

Abstract

ASJC Scopus subject areas

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