The role of stem cell transplantation in the management of chronic lymphocytic leukaemia

Constantine S. Tam, Issa Khouri

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

The majority of patients diagnosed with chronic lymphocytic leukaemia (CLL) will ultimately die of their disease. Stem cell transplantation (SCT) remains the only treatment modality capable of cure, but has traditionally been associated with very high morbidity and mortality. We review the results of myeloablative autologous and allogeneic SCT in CLL, discuss the evolution of the new non-myeloablative approaches, and make recommendations for when SCT should be considered in patients with CLL.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalHematological Oncology
Volume27
Issue number2
DOIs
StatePublished - 2009

Keywords

  • Alemtuzumab
  • Bone marrow transplantation
  • Reduced intensity conditioning
  • Rituximab

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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