The role of the cell adhesion molecules (integrins/cadherins) in prostate cancer

Alexandros Drivalos; Athanasios G. Papatsoris; Michael Chrisofos; Eleni Efstathiou; Meletios A. Dimopoulos

doi:10.1590/S1677-55382011000300002

The role of the cell adhesion molecules (integrins/cadherins) in prostate cancer

Alexandros Drivalos, Athanasios G. Papatsoris, Michael Chrisofos, Eleni Efstathiou, Meletios A. Dimopoulos

Genitourinary Medical Oncology

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are downregulated, while β subunits are up-regulated. The expression of several cadherins and catenins has specific prognostic value. There is an association between the expression of the E-cadherin/catenin complex and high grade prostate cancer. Clinical trials evaluating the efficacy of integrin antagonists are ongoing with promising results. In this article we update the role of integrins and cadherins in prostate carcinogenesis and evaluate the therapeutic potential of their manipulation.

Original language	English (US)
Pages (from-to)	302-306
Number of pages	5
Journal	International Braz J Urol
Volume	37
Issue number	3
DOIs	https://doi.org/10.1590/S1677-55382011000300002
State	Published - May 2011

Keywords

Cadherins
Integrins
Prostate cancer
Review

ASJC Scopus subject areas

Urology

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10.1590/S1677-55382011000300002

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title = "The role of the cell adhesion molecules (integrins/cadherins) in prostate cancer",

abstract = "During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are downregulated, while β subunits are up-regulated. The expression of several cadherins and catenins has specific prognostic value. There is an association between the expression of the E-cadherin/catenin complex and high grade prostate cancer. Clinical trials evaluating the efficacy of integrin antagonists are ongoing with promising results. In this article we update the role of integrins and cadherins in prostate carcinogenesis and evaluate the therapeutic potential of their manipulation.",

keywords = "Cadherins, Integrins, Prostate cancer, Review",

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AU - Drivalos, Alexandros

AU - Papatsoris, Athanasios G.

AU - Chrisofos, Michael

AU - Efstathiou, Eleni

AU - Dimopoulos, Meletios A.

PY - 2011/5

Y1 - 2011/5

N2 - During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are downregulated, while β subunits are up-regulated. The expression of several cadherins and catenins has specific prognostic value. There is an association between the expression of the E-cadherin/catenin complex and high grade prostate cancer. Clinical trials evaluating the efficacy of integrin antagonists are ongoing with promising results. In this article we update the role of integrins and cadherins in prostate carcinogenesis and evaluate the therapeutic potential of their manipulation.

AB - During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are downregulated, while β subunits are up-regulated. The expression of several cadherins and catenins has specific prognostic value. There is an association between the expression of the E-cadherin/catenin complex and high grade prostate cancer. Clinical trials evaluating the efficacy of integrin antagonists are ongoing with promising results. In this article we update the role of integrins and cadherins in prostate carcinogenesis and evaluate the therapeutic potential of their manipulation.

KW - Cadherins

KW - Integrins

KW - Prostate cancer

KW - Review

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The role of the cell adhesion molecules (integrins/cadherins) in prostate cancer

Abstract

Keywords

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