Abstract
IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies.
Original language | English (US) |
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Article number | 43 |
Journal | Molecular cancer |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Feb 15 2015 |
Externally published | Yes |
Keywords
- Breast cancer
- Estrogen receptor (ER)
- Estrogens
- IGF-1 receptor (IGF-1R)
- IGF-1 regulation
- IGF-1 signaling
- IGF-binding proteins (IGFBPs)
- Insulin-like growth factor-1 (IGF-1)
- Mammary tumorigenesis
ASJC Scopus subject areas
- Molecular Medicine
- Oncology
- Cancer Research