The role of the neu oncogene product in cell transformation and normal development.

Y. Kokai; T. Wada; J. N. Myers; V. I. Brown; K. Dobashi; J. Cohen; J. Hamuro; D. B. Weiner; M. I. Greene

The role of the neu oncogene product in cell transformation and normal development.

Y. Kokai, T. Wada, J. N. Myers, V. I. Brown, K. Dobashi, J. Cohen, J. Hamuro, D. B. Weiner, M. I. Greene

Research output: Contribution to journal › Review article › peer-review

Abstract

p185neu, the protein product of the neu gene, is a tyrosine kinase receptor with structural similarity to the epidermal growth factor (EGF) receptor. The cognate ligand for the p185neu receptor remains unknown. We have defined: 1) stage and tissue-specific expression patterns of the neu gene product in developing tissues; 2) p185neu phosphorylation and the regulation of p185neu tyrosine kinase activity by EGF. 3) Synergistic interactions of cellular rat p185neu and EGF receptor leading to cell transformation; 4) structural and functional differences of normal and oncogenic p185neu. These observations explain some features of how p185neu is involved in normal development and neoplastic transformation.

Original language	English (US)
Pages (from-to)	45-57
Number of pages	13
Journal	Princess Takamatsu symposia
Volume	19
State	Published - 1988
Externally published	Yes

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title = "The role of the neu oncogene product in cell transformation and normal development.",

abstract = "p185neu, the protein product of the neu gene, is a tyrosine kinase receptor with structural similarity to the epidermal growth factor (EGF) receptor. The cognate ligand for the p185neu receptor remains unknown. We have defined: 1) stage and tissue-specific expression patterns of the neu gene product in developing tissues; 2) p185neu phosphorylation and the regulation of p185neu tyrosine kinase activity by EGF. 3) Synergistic interactions of cellular rat p185neu and EGF receptor leading to cell transformation; 4) structural and functional differences of normal and oncogenic p185neu. These observations explain some features of how p185neu is involved in normal development and neoplastic transformation.",

author = "Y. Kokai and T. Wada and Myers, {J. N.} and Brown, {V. I.} and K. Dobashi and J. Cohen and J. Hamuro and Weiner, {D. B.} and Greene, {M. I.}",

year = "1988",

language = "English (US)",

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T1 - The role of the neu oncogene product in cell transformation and normal development.

AU - Kokai, Y.

AU - Wada, T.

AU - Myers, J. N.

AU - Brown, V. I.

AU - Dobashi, K.

AU - Cohen, J.

AU - Hamuro, J.

AU - Weiner, D. B.

AU - Greene, M. I.

PY - 1988

Y1 - 1988

N2 - p185neu, the protein product of the neu gene, is a tyrosine kinase receptor with structural similarity to the epidermal growth factor (EGF) receptor. The cognate ligand for the p185neu receptor remains unknown. We have defined: 1) stage and tissue-specific expression patterns of the neu gene product in developing tissues; 2) p185neu phosphorylation and the regulation of p185neu tyrosine kinase activity by EGF. 3) Synergistic interactions of cellular rat p185neu and EGF receptor leading to cell transformation; 4) structural and functional differences of normal and oncogenic p185neu. These observations explain some features of how p185neu is involved in normal development and neoplastic transformation.

AB - p185neu, the protein product of the neu gene, is a tyrosine kinase receptor with structural similarity to the epidermal growth factor (EGF) receptor. The cognate ligand for the p185neu receptor remains unknown. We have defined: 1) stage and tissue-specific expression patterns of the neu gene product in developing tissues; 2) p185neu phosphorylation and the regulation of p185neu tyrosine kinase activity by EGF. 3) Synergistic interactions of cellular rat p185neu and EGF receptor leading to cell transformation; 4) structural and functional differences of normal and oncogenic p185neu. These observations explain some features of how p185neu is involved in normal development and neoplastic transformation.

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M3 - Review article

C2 - 2908355

AN - SCOPUS:0024150035

VL - 19

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EP - 57

JO - Princess Takamatsu symposia

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The role of the neu oncogene product in cell transformation and normal development.

Abstract

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