Abstract
Background: Salivary ductal carcinoma (SDC) is a high-grade malignancy, and molecular studies show frequent overexpression of human epidermal growth factor receptor 2 (HER2). We reviewed our experience with molecular-targeted therapy using trastuzumab for patients with HER2-positive SDC. Patients and Methods: The records of all patients treated with trastuzumab for HER2-tested SDC at The University of Texas MD Anderson Cancer Center between 1997 and 2011 were reviewed. Results: Thirteen patients with SDC overexpressing HER2 were treated with trastuzumab as a single agent or in combination with chemotherapy. Ten of these had 3+ immunohistochemistry or HER2 gene amplification by fluorescence in situ hybridization. Patients underwent therapy in the surgical adjuvant setting (n=2), as a component of combined therapy for advanced disease (n=8), or as single therapy near end of life (n=3). Treatment efficacy via radiographic review for response could not be assessed. Conclusion: Trastuzumab should undergo prospective therapeutic clinical trials, in SDC which will likely require international cooperation.
Original language | English (US) |
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Pages (from-to) | 2587-2592 |
Number of pages | 6 |
Journal | Anticancer research |
Volume | 33 |
Issue number | 6 |
State | Published - Jun 2013 |
Keywords
- HER2/neu
- Molecular-targeted therapy
- Salivary ductal carcinoma
- Trastuzumab
ASJC Scopus subject areas
- Oncology
- Cancer Research