The roles of anoikis in cervical cancer

Yang Li; Shanshan Yang; Wei Hu; Anil K. Sood

doi:10.1007/978-3-030-73856-3_6

The roles of anoikis in cervical cancer

Yang Li, Shanshan Yang, Wei Hu, Anil K. Sood

Gynecological Oncology & Reproductive Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Cervical cancer is one of the most common malignancies in women worldwide. Tumor invasion and distant metastasis are among the main reasons for mortality in patients with cervical cancer. Resistance to anoikis is an important component of the multi-step cancer metastasis process. During this process, cancer cells utilize mechanisms to trigger survival signals and suppress death pathways, and take advantage of miRNAs or specific HPV oncogene variants to regulate anoikis. Chronic stress has been shown to contribute to tumor progression through norepinephrine-induced YAP1 activation and anoikis resistance. Norepinephrine binds to β-adrenergic receptors on the cancer cells to initiate downstream YAP signaling through cAMP/protein kinase A activation. YAP is dephosphorylated and translocated to the nucleus, protecting cancer cells from anoikis. YAP inhibitors may be useful for promoting anoikis and treating cervical and other cancers.

Original language	English (US)
Title of host publication	Anoikis
Subtitle of host publication	How the Extracellular Matrix Regulates Life-or-Death Decisions
Publisher	Springer
Pages	127-136
Number of pages	10
ISBN (Electronic)	9783030738563
ISBN (Print)	9783030738549
DOIs	https://doi.org/10.1007/978-3-030-73856-3_6
State	Published - Jul 27 2021

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1007/978-3-030-73856-3_6

Cite this

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title = "The roles of anoikis in cervical cancer",

abstract = "Cervical cancer is one of the most common malignancies in women worldwide. Tumor invasion and distant metastasis are among the main reasons for mortality in patients with cervical cancer. Resistance to anoikis is an important component of the multi-step cancer metastasis process. During this process, cancer cells utilize mechanisms to trigger survival signals and suppress death pathways, and take advantage of miRNAs or specific HPV oncogene variants to regulate anoikis. Chronic stress has been shown to contribute to tumor progression through norepinephrine-induced YAP1 activation and anoikis resistance. Norepinephrine binds to β-adrenergic receptors on the cancer cells to initiate downstream YAP signaling through cAMP/protein kinase A activation. YAP is dephosphorylated and translocated to the nucleus, protecting cancer cells from anoikis. YAP inhibitors may be useful for promoting anoikis and treating cervical and other cancers.",

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AU - Sood, Anil K.

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AB - Cervical cancer is one of the most common malignancies in women worldwide. Tumor invasion and distant metastasis are among the main reasons for mortality in patients with cervical cancer. Resistance to anoikis is an important component of the multi-step cancer metastasis process. During this process, cancer cells utilize mechanisms to trigger survival signals and suppress death pathways, and take advantage of miRNAs or specific HPV oncogene variants to regulate anoikis. Chronic stress has been shown to contribute to tumor progression through norepinephrine-induced YAP1 activation and anoikis resistance. Norepinephrine binds to β-adrenergic receptors on the cancer cells to initiate downstream YAP signaling through cAMP/protein kinase A activation. YAP is dephosphorylated and translocated to the nucleus, protecting cancer cells from anoikis. YAP inhibitors may be useful for promoting anoikis and treating cervical and other cancers.

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The roles of anoikis in cervical cancer

Abstract

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