TY - JOUR
T1 - The roles of chromatin remodeling proteins in cancer
AU - Zhang, Chun
AU - Lu, Jie
AU - Zhang, Pingyu
N1 - Funding Information:
We apologize to those researchers whose works are not cited here because of the space limitations. This work was supported by the National Natural Science Foundation of China (81201120) to Chun Zhang.
Publisher Copyright:
© 2016 Bentham Science Publishers.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Chromatin remodeling complexes (chromatin remodelers) have been demonstrated as essential and powerful regulators for critical DNA-templated cellular processes, such as DNA replication, recombination, gene transcription/repression, and DNA damage repair. These molecular and genetic processes are important for a wide spectrum of cellular functions including, cell cycle, death, differentiation, pluripotency, and genome integrity. Not surprisingly, dysfunctions of chromatin remodeling proteins are observed in human developmental disorders and diseases. Specifically for human malignancies, genomic sequence analyses show that mutations and other genetic alternations of chromatin remodelers exist in almost all human tumor types. Using human cancer cell lines, xenograft models and genetically engineered mouse models, functions of chromatin remodelers in human cancers have been studied extensively in the last 10-15 years. In this review, we summarize the functional and mechanistic studies of chromatin remodelers in the initiation, progression and metastasis of human cancers.
AB - Chromatin remodeling complexes (chromatin remodelers) have been demonstrated as essential and powerful regulators for critical DNA-templated cellular processes, such as DNA replication, recombination, gene transcription/repression, and DNA damage repair. These molecular and genetic processes are important for a wide spectrum of cellular functions including, cell cycle, death, differentiation, pluripotency, and genome integrity. Not surprisingly, dysfunctions of chromatin remodeling proteins are observed in human developmental disorders and diseases. Specifically for human malignancies, genomic sequence analyses show that mutations and other genetic alternations of chromatin remodelers exist in almost all human tumor types. Using human cancer cell lines, xenograft models and genetically engineered mouse models, functions of chromatin remodelers in human cancers have been studied extensively in the last 10-15 years. In this review, we summarize the functional and mechanistic studies of chromatin remodelers in the initiation, progression and metastasis of human cancers.
KW - Cancer
KW - Chromatin
KW - Chromatin remodeling
KW - Chromatin remodeling protein
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U2 - 10.2174/1389203717666160122120713
DO - 10.2174/1389203717666160122120713
M3 - Article
C2 - 26796304
AN - SCOPUS:84973639257
SN - 1389-2037
VL - 17
SP - 446
EP - 454
JO - Current Protein and Peptide Science
JF - Current Protein and Peptide Science
IS - 5
ER -