TY - JOUR
T1 - The roles of interleukin-15 receptor α
T2 - Trans-presentation, receptor component, or both?
AU - Schluns, Kimberly S.
AU - Stoklasek, Thomas
AU - Lefrançois, Leo
N1 - Funding Information:
Work in our laboratory is supported by grants from the National Institutes of Health.
PY - 2005/8
Y1 - 2005/8
N2 - Interleukin-15 receptor α (IL-15Rα) is a high affinity IL-15 binding protein that is crucial for mediating IL-15 functions such as memory CD8 T cell proliferation and NK, NK/T cell, and intestinal intraepithelial lymphocyte development. However, the mechanism by which IL-15Rα mediates IL-15 functions is unique among cytokines. Originally, IL-15Rα was thought to be a component of a heterotrimeric receptor complex containing the IL-2/IL-15Rβ and common γ chains (γC) that were required for mediating signaling. Although IL-15Rα may in some cases act as a component of this receptor complex, more recent evidence indicates that IL-15Rα predominately functions by presenting IL-15 to opposing cells expressing the IL-15Rβγ signaling components. This theory is consistent with the broad, non-lymphoid expression pattern of IL-15Rα and the evidence that IL-15Rα expression by lymphocytes is dispensable for IL-15 action in vivo. This new concept of cytokine delivery will allow us to better understand the regulation and function IL-15.
AB - Interleukin-15 receptor α (IL-15Rα) is a high affinity IL-15 binding protein that is crucial for mediating IL-15 functions such as memory CD8 T cell proliferation and NK, NK/T cell, and intestinal intraepithelial lymphocyte development. However, the mechanism by which IL-15Rα mediates IL-15 functions is unique among cytokines. Originally, IL-15Rα was thought to be a component of a heterotrimeric receptor complex containing the IL-2/IL-15Rβ and common γ chains (γC) that were required for mediating signaling. Although IL-15Rα may in some cases act as a component of this receptor complex, more recent evidence indicates that IL-15Rα predominately functions by presenting IL-15 to opposing cells expressing the IL-15Rβγ signaling components. This theory is consistent with the broad, non-lymphoid expression pattern of IL-15Rα and the evidence that IL-15Rα expression by lymphocytes is dispensable for IL-15 action in vivo. This new concept of cytokine delivery will allow us to better understand the regulation and function IL-15.
KW - Cytokine
KW - IL-15
KW - Immunological memory
KW - Lymphoid development
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U2 - 10.1016/j.biocel.2005.02.017
DO - 10.1016/j.biocel.2005.02.017
M3 - Short survey
C2 - 15896666
AN - SCOPUS:19344368323
SN - 1357-2725
VL - 37
SP - 1567
EP - 1571
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 8
ER -