The scintigraphic localization of mineralocorticoid-producing adrenocortical carcinoma

Y. Shenker; M. D. Gross; R. J. Grekin; S. G. Rosen; J. A. Sanfield; B. Shapiro; B. Samuels; W. Strodel; N. W. Thompson; T. F. Beals; R. V. Lloyd

doi:10.1007/BF03348080

The scintigraphic localization of mineralocorticoid-producing adrenocortical carcinoma

Y. Shenker, M. D. Gross, R. J. Grekin, S. G. Rosen, J. A. Sanfield, B. Shapiro, B. Samuels, W. Strodel, N. W. Thompson, T. F. Beals, R. V. Lloyd

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

I-131-6 β-iodomethylnorcholesterol (NP-59) was used to localize mineralocorticoid-secreting adrenocortical carcinomas in two patients and functioning metastases in a third patient studied after the removal of the primary tumor. The presence of sufficient NP-59 activity within these lesions for discernable imaging is unusual and would not have been expected based on previous experience with other functioning and nonfunctioning carcinomas of the adrenal cortex. These cases serve to illustrate the variable spectrum of iodocholesterol uptake into adrenocortical malignancies and suggest that scintigraphic studies, preoperatively for localization and postoperatively to confirm the presence of recurrence or metastases, might be useful to identify and characterize these rare neoplasms.

Original language	English (US)
Pages (from-to)	115-120
Number of pages	6
Journal	Journal of Endocrinological Investigation
Volume	9
Issue number	2
DOIs	https://doi.org/10.1007/BF03348080
State	Published - Apr 1986

Keywords

Adrenal
carcinoma
iodocholesterol
mineralocorticoid
scintigraphy

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1007/BF03348080

Cite this

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title = "The scintigraphic localization of mineralocorticoid-producing adrenocortical carcinoma",

abstract = "I-131-6 β-iodomethylnorcholesterol (NP-59) was used to localize mineralocorticoid-secreting adrenocortical carcinomas in two patients and functioning metastases in a third patient studied after the removal of the primary tumor. The presence of sufficient NP-59 activity within these lesions for discernable imaging is unusual and would not have been expected based on previous experience with other functioning and nonfunctioning carcinomas of the adrenal cortex. These cases serve to illustrate the variable spectrum of iodocholesterol uptake into adrenocortical malignancies and suggest that scintigraphic studies, preoperatively for localization and postoperatively to confirm the presence of recurrence or metastases, might be useful to identify and characterize these rare neoplasms.",

keywords = "Adrenal, carcinoma, iodocholesterol, mineralocorticoid, scintigraphy",

author = "Y. Shenker and Gross, {M. D.} and Grekin, {R. J.} and Rosen, {S. G.} and Sanfield, {J. A.} and B. Shapiro and B. Samuels and W. Strodel and Thompson, {N. W.} and Beals, {T. F.} and Lloyd, {R. V.}",

year = "1986",

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T1 - The scintigraphic localization of mineralocorticoid-producing adrenocortical carcinoma

AU - Shenker, Y.

AU - Gross, M. D.

AU - Grekin, R. J.

AU - Rosen, S. G.

AU - Sanfield, J. A.

AU - Shapiro, B.

AU - Samuels, B.

AU - Strodel, W.

AU - Thompson, N. W.

AU - Beals, T. F.

AU - Lloyd, R. V.

PY - 1986/4

Y1 - 1986/4

N2 - I-131-6 β-iodomethylnorcholesterol (NP-59) was used to localize mineralocorticoid-secreting adrenocortical carcinomas in two patients and functioning metastases in a third patient studied after the removal of the primary tumor. The presence of sufficient NP-59 activity within these lesions for discernable imaging is unusual and would not have been expected based on previous experience with other functioning and nonfunctioning carcinomas of the adrenal cortex. These cases serve to illustrate the variable spectrum of iodocholesterol uptake into adrenocortical malignancies and suggest that scintigraphic studies, preoperatively for localization and postoperatively to confirm the presence of recurrence or metastases, might be useful to identify and characterize these rare neoplasms.

AB - I-131-6 β-iodomethylnorcholesterol (NP-59) was used to localize mineralocorticoid-secreting adrenocortical carcinomas in two patients and functioning metastases in a third patient studied after the removal of the primary tumor. The presence of sufficient NP-59 activity within these lesions for discernable imaging is unusual and would not have been expected based on previous experience with other functioning and nonfunctioning carcinomas of the adrenal cortex. These cases serve to illustrate the variable spectrum of iodocholesterol uptake into adrenocortical malignancies and suggest that scintigraphic studies, preoperatively for localization and postoperatively to confirm the presence of recurrence or metastases, might be useful to identify and characterize these rare neoplasms.

KW - Adrenal

KW - carcinoma

KW - iodocholesterol

KW - mineralocorticoid

KW - scintigraphy

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The scintigraphic localization of mineralocorticoid-producing adrenocortical carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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