The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration

J. Matthew McDonald; Sarah Dunlap; David Cogdell; Valerie Dunmire; Qingyi Wei; Anna Starzinski-Powitz; Raymond Sawaya; Janet Bruner; Gregory N. Fuller; Kenneth Aldape; Wei Zhang

doi:10.4161/cbt.5.3.2391

The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration

J. Matthew McDonald, Sarah Dunlap, David Cogdell, Valerie Dunmire, Qingyi Wei, Anna Starzinski-Powitz, Raymond Sawaya, Janet Bruner, Gregory N. Fuller, Kenneth Aldape, Wei Zhang

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene, SHREW1, which encodes a novel transmembrane protein in adherens junctions. Whereas a mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, restoration of SHREW1 expression resulted in suppression of cell adhesion and migration. Thus, SHREW1 inactivation may play a role in the development of oligodendroglial tumors.

Original language	English (US)
Pages (from-to)	300-304
Number of pages	5
Journal	Cancer Biology and Therapy
Volume	5
Issue number	3
DOIs	https://doi.org/10.4161/cbt.5.3.2391
State	Published - Mar 2006

Keywords

1p36
Allelic loss
Cell adhesion
Oligodendroglioma
QuMA
SHREW1

ASJC Scopus subject areas

Molecular Medicine
Oncology
Pharmacology
Cancer Research

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10.4161/cbt.5.3.2391

Cite this

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title = "The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration",

abstract = "Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene, SHREW1, which encodes a novel transmembrane protein in adherens junctions. Whereas a mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, restoration of SHREW1 expression resulted in suppression of cell adhesion and migration. Thus, SHREW1 inactivation may play a role in the development of oligodendroglial tumors.",

keywords = "1p36, Allelic loss, Cell adhesion, Oligodendroglioma, QuMA, SHREW1",

author = "McDonald, {J. Matthew} and Sarah Dunlap and David Cogdell and Valerie Dunmire and Qingyi Wei and Anna Starzinski-Powitz and Raymond Sawaya and Janet Bruner and Fuller, {Gregory N.} and Kenneth Aldape and Wei Zhang",

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doi = "10.4161/cbt.5.3.2391",

language = "English (US)",

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journal = "Cancer Biology and Therapy",

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T1 - The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration

AU - McDonald, J. Matthew

AU - Dunlap, Sarah

AU - Cogdell, David

AU - Dunmire, Valerie

AU - Wei, Qingyi

AU - Starzinski-Powitz, Anna

AU - Sawaya, Raymond

AU - Bruner, Janet

AU - Fuller, Gregory N.

AU - Aldape, Kenneth

AU - Zhang, Wei

PY - 2006/3

Y1 - 2006/3

N2 - Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene, SHREW1, which encodes a novel transmembrane protein in adherens junctions. Whereas a mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, restoration of SHREW1 expression resulted in suppression of cell adhesion and migration. Thus, SHREW1 inactivation may play a role in the development of oligodendroglial tumors.

AB - Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene, SHREW1, which encodes a novel transmembrane protein in adherens junctions. Whereas a mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, restoration of SHREW1 expression resulted in suppression of cell adhesion and migration. Thus, SHREW1 inactivation may play a role in the development of oligodendroglial tumors.

KW - 1p36

KW - Allelic loss

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The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration

Abstract

Keywords

ASJC Scopus subject areas

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