The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development

Haiyan S. Li; Cliff Y. Yang; Kalyan C. Nallaparaju; Huiyuan Zhang; Yong Jun Liu; Ananda W. Goldrath; Stephanie S. Watowich

doi:10.1182/blood-2012-07-441311

The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development

Haiyan S. Li, Cliff Y. Yang, Kalyan C. Nallaparaju, Huiyuan Zhang, Yong Jun Liu, Ananda W. Goldrath, Stephanie S. Watowich

Immunology

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Cytokines and transcription factors play key roles in dendritic cell (DC) development, yet information about regulatory interactions between these signals remains limited. Here we show that the cytokines GM-CSF and Flt3L induce the transcriptional mediators Id2 and E2-2 and control DC lineage diversification by STAT-dependent pathways.We found that STAT5 is required for tissue CD103 ⁺ DC generation and plasmacytoid DC (pDC) suppression in steady state or response to GM-CSF. STAT5 stimulates GM-CSF-dependent expression of Id2, which controls CD103⁺ DC production and pDC inhibition. By contrast, pDCs, but not CD103⁺ DCs, are dependent on STAT3. Consistently, STAT3 stimulates Flt3L-responsive expression of the pDC regulator Tcf4 (E2-2). These data suggest that STATs contribute to DC development by controlling transcription factors involved in lineage differentiation.

Original language	English (US)
Pages (from-to)	4363-4373
Number of pages	11
Journal	Blood
Volume	120
Issue number	22
DOIs	https://doi.org/10.1182/blood-2012-07-441311
State	Published - Nov 22 2012

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood-2012-07-441311

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title = "The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development",

abstract = "Cytokines and transcription factors play key roles in dendritic cell (DC) development, yet information about regulatory interactions between these signals remains limited. Here we show that the cytokines GM-CSF and Flt3L induce the transcriptional mediators Id2 and E2-2 and control DC lineage diversification by STAT-dependent pathways.We found that STAT5 is required for tissue CD103 + DC generation and plasmacytoid DC (pDC) suppression in steady state or response to GM-CSF. STAT5 stimulates GM-CSF-dependent expression of Id2, which controls CD103+ DC production and pDC inhibition. By contrast, pDCs, but not CD103+ DCs, are dependent on STAT3. Consistently, STAT3 stimulates Flt3L-responsive expression of the pDC regulator Tcf4 (E2-2). These data suggest that STATs contribute to DC development by controlling transcription factors involved in lineage differentiation.",

author = "Li, {Haiyan S.} and Yang, {Cliff Y.} and Nallaparaju, {Kalyan C.} and Huiyuan Zhang and Liu, {Yong Jun} and Goldrath, {Ananda W.} and Watowich, {Stephanie S.}",

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doi = "10.1182/blood-2012-07-441311",

language = "English (US)",

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T1 - The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development

AU - Li, Haiyan S.

AU - Yang, Cliff Y.

AU - Nallaparaju, Kalyan C.

AU - Zhang, Huiyuan

AU - Liu, Yong Jun

AU - Goldrath, Ananda W.

AU - Watowich, Stephanie S.

PY - 2012/11/22

Y1 - 2012/11/22

N2 - Cytokines and transcription factors play key roles in dendritic cell (DC) development, yet information about regulatory interactions between these signals remains limited. Here we show that the cytokines GM-CSF and Flt3L induce the transcriptional mediators Id2 and E2-2 and control DC lineage diversification by STAT-dependent pathways.We found that STAT5 is required for tissue CD103 + DC generation and plasmacytoid DC (pDC) suppression in steady state or response to GM-CSF. STAT5 stimulates GM-CSF-dependent expression of Id2, which controls CD103+ DC production and pDC inhibition. By contrast, pDCs, but not CD103+ DCs, are dependent on STAT3. Consistently, STAT3 stimulates Flt3L-responsive expression of the pDC regulator Tcf4 (E2-2). These data suggest that STATs contribute to DC development by controlling transcription factors involved in lineage differentiation.

AB - Cytokines and transcription factors play key roles in dendritic cell (DC) development, yet information about regulatory interactions between these signals remains limited. Here we show that the cytokines GM-CSF and Flt3L induce the transcriptional mediators Id2 and E2-2 and control DC lineage diversification by STAT-dependent pathways.We found that STAT5 is required for tissue CD103 + DC generation and plasmacytoid DC (pDC) suppression in steady state or response to GM-CSF. STAT5 stimulates GM-CSF-dependent expression of Id2, which controls CD103+ DC production and pDC inhibition. By contrast, pDCs, but not CD103+ DCs, are dependent on STAT3. Consistently, STAT3 stimulates Flt3L-responsive expression of the pDC regulator Tcf4 (E2-2). These data suggest that STATs contribute to DC development by controlling transcription factors involved in lineage differentiation.

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The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development

Abstract

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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