The T-cell antigen receptor gamma gene: rearrangement and cell lineages

James P. Allison; Lewis L. Lanier

doi:10.1016/0167-5699(87)90014-4

The T-cell antigen receptor gamma gene: rearrangement and cell lineages

James P. Allison, Lewis L. Lanier

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Most adult T cells have a T-cell antigen receptor composed of αß heterodimers in a complex with the CD3 antigen. Immature thymocytes, however, can express CD3-associated heterodimers of a γ chain and another poorly characterized chain ('δ'). Here James Allison and Lewis Lanier suggest that thymocytes can develop along two mutually exclusive ontological pathways, giving rise to T cells that express either αß or γδ heterodimers, but not both or any other heterodimeric combination.

Original language	English (US)
Pages (from-to)	293-296
Number of pages	4
Journal	Immunology Today
Volume	8
Issue number	10
DOIs	https://doi.org/10.1016/0167-5699(87)90014-4
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/0167-5699(87)90014-4

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AU - Lanier, Lewis L.

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AB - Most adult T cells have a T-cell antigen receptor composed of αß heterodimers in a complex with the CD3 antigen. Immature thymocytes, however, can express CD3-associated heterodimers of a γ chain and another poorly characterized chain ('δ'). Here James Allison and Lewis Lanier suggest that thymocytes can develop along two mutually exclusive ontological pathways, giving rise to T cells that express either αß or γδ heterodimers, but not both or any other heterodimeric combination.

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The T-cell antigen receptor gamma gene: rearrangement and cell lineages

Abstract

ASJC Scopus subject areas

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