TY - JOUR
T1 - The t(14;19)(q32;q13)-positive small B-cell leukaemia
T2 - A clinicopathologic and cytogenetic study of seven cases
AU - Huh, Yang O.
AU - Abruzzo, Lynne V.
AU - Rassidakis, George Z.
AU - Parry-Jones, Nilima
AU - Schlette, Ellen
AU - Brito-Bapabulle, Vasantha
AU - Matutes, Estella
AU - Wotherspoon, Andrew
AU - Keating, Michael J.
AU - Medeiros, L. Jeffrey
AU - Catovsky, Daniel
PY - 2007/1
Y1 - 2007/1
N2 - The t(14;19)(q32;q13), involving the BCL3 locus at chromosome 19q13 and the immunoglobulin heavy chain gene at 14q32, is a rare recurrent cytogenetic abnormality identified in B-cell neoplasms, most of which have been classified as chronic lymphocytic leukaemia (CLL) in the literature. We describe the clinicopathological, immunophenotypic and cytogenetic findings in seven patients with B-cell neoplasms associated with t(14;19)(q32;q13). There were five men and two women, with a median age of 48 years (range 33-68). All had absolute lymphocytosis, six had lymphadenopathy, and one had splenomegaly. Lymphocytes in blood and bone marrow aspirate smears were predominantly small and cytologically atypical. Flow cytometric immunophenotyping showed an atypical immunophenotype with low CLL scores. The growth pattern in bone marrow biopsy specimens was interstitial to diffuse; immunohistochemical stains were positive for bcl3 and negative for cyclin D1. Lymph node biopsy specimens of two patients revealed total architectural effacement by neoplasm with proliferation centres. In addition to t(14;19), cytogenetic studies demonstrated trisomy 12 in five patients. These results suggest that B-cell neoplasms with the t(14;19)(q32;q13) present frequently as leukaemia composed of small B-lymphocytes and share many features with CLL. However, these neoplasms also differ from CLL cytologically and in their immunophenotype.
AB - The t(14;19)(q32;q13), involving the BCL3 locus at chromosome 19q13 and the immunoglobulin heavy chain gene at 14q32, is a rare recurrent cytogenetic abnormality identified in B-cell neoplasms, most of which have been classified as chronic lymphocytic leukaemia (CLL) in the literature. We describe the clinicopathological, immunophenotypic and cytogenetic findings in seven patients with B-cell neoplasms associated with t(14;19)(q32;q13). There were five men and two women, with a median age of 48 years (range 33-68). All had absolute lymphocytosis, six had lymphadenopathy, and one had splenomegaly. Lymphocytes in blood and bone marrow aspirate smears were predominantly small and cytologically atypical. Flow cytometric immunophenotyping showed an atypical immunophenotype with low CLL scores. The growth pattern in bone marrow biopsy specimens was interstitial to diffuse; immunohistochemical stains were positive for bcl3 and negative for cyclin D1. Lymph node biopsy specimens of two patients revealed total architectural effacement by neoplasm with proliferation centres. In addition to t(14;19), cytogenetic studies demonstrated trisomy 12 in five patients. These results suggest that B-cell neoplasms with the t(14;19)(q32;q13) present frequently as leukaemia composed of small B-lymphocytes and share many features with CLL. However, these neoplasms also differ from CLL cytologically and in their immunophenotype.
KW - Atypical morphology
KW - Chronic lymphocytic leukaemia
KW - Immunophenotype
KW - bcl3
KW - t(14;19)
UR - http://www.scopus.com/inward/record.url?scp=33845880888&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845880888&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.2006.06416.x
DO - 10.1111/j.1365-2141.2006.06416.x
M3 - Article
C2 - 17129229
AN - SCOPUS:33845880888
SN - 0007-1048
VL - 136
SP - 220
EP - 228
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 2
ER -