TY - JOUR
T1 - The technique of premature chromosome condensation to study the leukemic process
T2 - Review and speculations
AU - Hittelman, Walter N.
AU - Preisler, Harvey D.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1986
Y1 - 1986
N2 - The technique of premature chromosome condensation involves the fusion of mitotic cells with interphase cells resulting in the immediate condensation of the interphase chromatin into discrete chromosome units, the prematurely condensed chromosomes (PCC). The ability to visualize the interphase chromosomes of bone marrow and blood cells by this technique has proved useful in the study of human leukemia. This article describes how the PCC technique has been used to predict clinical outcome as well as gain insight into the biology of leukemia.
AB - The technique of premature chromosome condensation involves the fusion of mitotic cells with interphase cells resulting in the immediate condensation of the interphase chromatin into discrete chromosome units, the prematurely condensed chromosomes (PCC). The ability to visualize the interphase chromosomes of bone marrow and blood cells by this technique has proved useful in the study of human leukemia. This article describes how the PCC technique has been used to predict clinical outcome as well as gain insight into the biology of leukemia.
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U2 - 10.1016/S1040-8428(86)80020-8
DO - 10.1016/S1040-8428(86)80020-8
M3 - Review article
C2 - 3539379
AN - SCOPUS:0022959937
SN - 1040-8428
VL - 6
SP - 147
EP - 221
JO - Critical Reviews in Oncology and Hematology
JF - Critical Reviews in Oncology and Hematology
IS - 2
ER -