TY - JOUR
T1 - The Th1-specific costimulatory molecule, M150, is a posttranslational isoform of lysosome-associated membrane protein-1
AU - Prasad, Durbaka V.R.
AU - Parekh, Vrajesh V.
AU - Joshi, Bimba N.
AU - Banerjee, Pinaki P.
AU - Parab, Pradeep B.
AU - Chattopadhyay, Samit
AU - Kumar, Anil
AU - Mishra, Gyan C.
PY - 2002/8/15
Y1 - 2002/8/15
N2 - In an earlier report, we had shown a 150-kDa protein termed as M150, isolated from the surface of activated macrophages, to possess costimulatory activity for CD4+ T cells. Significantly, this protein was found to specifically elicit Th1 responses. In this study, we characterize M150, which belongs to a unique subset of the lysosome-associated membrane protein-1 glycoprotein. Interestingly, the costimulatory activity of M150 depends on its posttranslational modification, which has a distinct glycosylation pattern restricted to macrophages. Furthermore, it has been demonstrated that in addition to stimulating Th1-specific responses, M150 is also capable of driving differentiation of naive CD4+ T cells into the Th1 subset. This altered posttranslational modification of housekeeping protein appears to represent a novel pathway by which APCs can additionally regulate T cell responses.
AB - In an earlier report, we had shown a 150-kDa protein termed as M150, isolated from the surface of activated macrophages, to possess costimulatory activity for CD4+ T cells. Significantly, this protein was found to specifically elicit Th1 responses. In this study, we characterize M150, which belongs to a unique subset of the lysosome-associated membrane protein-1 glycoprotein. Interestingly, the costimulatory activity of M150 depends on its posttranslational modification, which has a distinct glycosylation pattern restricted to macrophages. Furthermore, it has been demonstrated that in addition to stimulating Th1-specific responses, M150 is also capable of driving differentiation of naive CD4+ T cells into the Th1 subset. This altered posttranslational modification of housekeeping protein appears to represent a novel pathway by which APCs can additionally regulate T cell responses.
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U2 - 10.4049/jimmunol.169.4.1801
DO - 10.4049/jimmunol.169.4.1801
M3 - Article
C2 - 12165502
AN - SCOPUS:0037103281
SN - 0022-1767
VL - 169
SP - 1801
EP - 1809
JO - Journal of Immunology
JF - Journal of Immunology
IS - 4
ER -