The Therapeutic Potential of FLASH-RT for Pancreatic Cancer

Chidi M. Okoro; Emil Schüler; Cullen M. Taniguchi

doi:10.3390/cancers14051167

The Therapeutic Potential of FLASH-RT for Pancreatic Cancer

Chidi M. Okoro, Emil Schüler, Cullen M. Taniguchi

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Recent preclinical evidence has shown that ionizing radiation given at an ultra-high dose rate (UHDR), also known as FLASH radiation therapy (FLASH-RT), can selectively reduce radiation injury to normal tissue while remaining isoeffective to conventional radiation therapy (CONV-RT) with respect to tumor killing. Unresectable pancreatic cancer is challenging to control without ablative doses of radiation, but this is difficult to achieve without significant gastrointestinal toxicity. In this review article, we explore the propsed mechanisms of FLASH-RT and its tissue-sparing effect, as well as its relevance and suitability for the treatment of pancreatic cancer. We also briefly discuss the challenges with regard to dosimetry, dose rate, and fractionation for using FLASH-RT to treat this disease.

Original language	English (US)
Article number	1167
Journal	Cancers
Volume	14
Issue number	5
DOIs	https://doi.org/10.3390/cancers14051167
State	Published - Mar 1 2022

Keywords

Conventional radiation
FLASH effect
FLASH radiation
Gastrointestinal toxicity
Pancreatic cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers14051167

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abstract = "Recent preclinical evidence has shown that ionizing radiation given at an ultra-high dose rate (UHDR), also known as FLASH radiation therapy (FLASH-RT), can selectively reduce radiation injury to normal tissue while remaining isoeffective to conventional radiation therapy (CONV-RT) with respect to tumor killing. Unresectable pancreatic cancer is challenging to control without ablative doses of radiation, but this is difficult to achieve without significant gastrointestinal toxicity. In this review article, we explore the propsed mechanisms of FLASH-RT and its tissue-sparing effect, as well as its relevance and suitability for the treatment of pancreatic cancer. We also briefly discuss the challenges with regard to dosimetry, dose rate, and fractionation for using FLASH-RT to treat this disease.",

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AU - Schüler, Emil

AU - Taniguchi, Cullen M.

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The Therapeutic Potential of FLASH-RT for Pancreatic Cancer

Abstract

Keywords

ASJC Scopus subject areas

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