The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Donna M. Stone; Mary Hynes; Mark Armanini; Todd A. Swanson; Qimin Gu; Ronald L. Johnson; Matthew P. Scott; Diane Pennica; Audrey Goddard; Heidi Phillips; Markus Noll; Joan E. Hooper; Frederic De Sauvage; Arnon Rosenthal

doi:10.1038/384129a0

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Donna M. Stone, Mary Hynes, Mark Armanini, Todd A. Swanson, Qimin Gu, Ronald L. Johnson, Matthew P. Scott, Diane Pennica, Audrey Goddard, Heidi Phillips, Markus Noll, Joan E. Hooper, Frederic De Sauvage, Arnon Rosenthal

Research output: Contribution to journal › Article › peer-review

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Abstract

The protein Sonic hedgehog (Shh) controls patterning and growth during vertebrate development. Here we demonstrate that it binds Patched (vPtc), which has been identified as a tumour-suppressor protein in basal cell carcinoma, with high affinity. We show that Ptc can form a physical complex with a newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly. These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc.

Original language	English (US)
Pages (from-to)	129-134
Number of pages	6
Journal	Nature
Volume	384
Issue number	6605
DOIs	https://doi.org/10.1038/384129a0
State	Published - Nov 14 1996
Externally published	Yes

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title = "The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog",

abstract = "The protein Sonic hedgehog (Shh) controls patterning and growth during vertebrate development. Here we demonstrate that it binds Patched (vPtc), which has been identified as a tumour-suppressor protein in basal cell carcinoma, with high affinity. We show that Ptc can form a physical complex with a newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly. These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc.",

author = "Stone, {Donna M.} and Mary Hynes and Mark Armanini and Swanson, {Todd A.} and Qimin Gu and Johnson, {Ronald L.} and Scott, {Matthew P.} and Diane Pennica and Audrey Goddard and Heidi Phillips and Markus Noll and Hooper, {Joan E.} and {De Sauvage}, Frederic and Arnon Rosenthal",

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doi = "10.1038/384129a0",

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T1 - The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

AU - Stone, Donna M.

AU - Hynes, Mary

AU - Armanini, Mark

AU - Swanson, Todd A.

AU - Gu, Qimin

AU - Johnson, Ronald L.

AU - Scott, Matthew P.

AU - Pennica, Diane

AU - Goddard, Audrey

AU - Phillips, Heidi

AU - Noll, Markus

AU - Hooper, Joan E.

AU - De Sauvage, Frederic

AU - Rosenthal, Arnon

PY - 1996/11/14

Y1 - 1996/11/14

N2 - The protein Sonic hedgehog (Shh) controls patterning and growth during vertebrate development. Here we demonstrate that it binds Patched (vPtc), which has been identified as a tumour-suppressor protein in basal cell carcinoma, with high affinity. We show that Ptc can form a physical complex with a newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly. These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc.

AB - The protein Sonic hedgehog (Shh) controls patterning and growth during vertebrate development. Here we demonstrate that it binds Patched (vPtc), which has been identified as a tumour-suppressor protein in basal cell carcinoma, with high affinity. We show that Ptc can form a physical complex with a newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly. These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc.

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The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Abstract

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