TY - JOUR
T1 - The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer
AU - Guan, Xiaoxiang
AU - Zhao, Hui
AU - Niu, Jiangong
AU - Tang, Dongfeng
AU - Ajani, Jaffer A.
AU - Wei, Qingyi
N1 - Funding Information:
This study was in part supported by National Institutes of Health grants R01 ES 011740-07 and CA 131274-01 (to Q. W.) and CA 016672 (to M. D. Anderson Cancer Center). We thank Margaret Lung and Kathryn Tipton for their assistance in recruiting the subjects and Min Zhao, Jianzhong He and Kejin Xu for their laboratory assistance, and Zhensheng Liu for laboratory management and Li-E Wang for data management.
PY - 2009/10/16
Y1 - 2009/10/16
N2 - Background: Both TGF-β1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population. Methods: The risk associated with genotypes and haplotypes of four TGFB1 SNPs and four VEGF SNPs were determined by multivariate logistic regression analysis in 171 patients with gastric cancer and 353 cancer-free controls frequency-matched by age, sex and ethnicity. Results: Compared with the VEGF-634GG genotype, the -634CG genotype and the combined -634CG+CC genotypes were associated with a significantly elevated risk of gastric cancer (adjusted OR = 1.88, 95% CI = 1.24-2.86 and adjusted OR = 1.56, 95% CI = 1.07-2.27, respectively). However, none of other TGFB1 and VEGF SNPs was associated with risk of gastric cancer. Conclusion: Our data suggested that the VEGF-634G>C SNP may be a marker for susceptibility to gastric cancer, and this finding needs to be validated in larger studies.
AB - Background: Both TGF-β1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population. Methods: The risk associated with genotypes and haplotypes of four TGFB1 SNPs and four VEGF SNPs were determined by multivariate logistic regression analysis in 171 patients with gastric cancer and 353 cancer-free controls frequency-matched by age, sex and ethnicity. Results: Compared with the VEGF-634GG genotype, the -634CG genotype and the combined -634CG+CC genotypes were associated with a significantly elevated risk of gastric cancer (adjusted OR = 1.88, 95% CI = 1.24-2.86 and adjusted OR = 1.56, 95% CI = 1.07-2.27, respectively). However, none of other TGFB1 and VEGF SNPs was associated with risk of gastric cancer. Conclusion: Our data suggested that the VEGF-634G>C SNP may be a marker for susceptibility to gastric cancer, and this finding needs to be validated in larger studies.
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U2 - 10.1186/1471-230X-9-77
DO - 10.1186/1471-230X-9-77
M3 - Article
C2 - 19835575
AN - SCOPUS:70549107877
SN - 1471-230X
VL - 9
SP - 77
JO - BMC Gastroenterology
JF - BMC Gastroenterology
M1 - 1471
ER -