TY - JOUR
T1 - Theoretical effects of transmembrane electroneutral exchange on membrane potential
AU - Jacob, Ron
AU - Piwnica-Worms, David
AU - Russell Horres, C.
AU - Lieberman, Melvyn
PY - 1984/1/1
Y1 - 1984/1/1
N2 - Transmembrane electroneutral transport mechanisms [e.g., Na/H exchange, Cl/HCO3 exchange, (K + Cl) cotransport] have recently been identified in a wide variety of cell types. If these exchanges sum to give a net electroneutral Na/K exchange, they may hyperpolarize the membrane potential beyond the value calculated from the Mullins-Nods equation, provided the cell maintains steady state intracellular ionic concentrations. In extreme circumstances, the membrane potential could hyperpolarize beyond the potassium reversal potential. This effect is mediated by the electrogenic Na/K pump. If either Na or K exchanges electroneutrally against a third ion (e.g., Na/Ca exchange), then the exchange may depolarize the membrane potential.
AB - Transmembrane electroneutral transport mechanisms [e.g., Na/H exchange, Cl/HCO3 exchange, (K + Cl) cotransport] have recently been identified in a wide variety of cell types. If these exchanges sum to give a net electroneutral Na/K exchange, they may hyperpolarize the membrane potential beyond the value calculated from the Mullins-Nods equation, provided the cell maintains steady state intracellular ionic concentrations. In extreme circumstances, the membrane potential could hyperpolarize beyond the potassium reversal potential. This effect is mediated by the electrogenic Na/K pump. If either Na or K exchanges electroneutrally against a third ion (e.g., Na/Ca exchange), then the exchange may depolarize the membrane potential.
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U2 - 10.1085/jgp.83.1.47
DO - 10.1085/jgp.83.1.47
M3 - Article
C2 - 6319544
AN - SCOPUS:0021342590
SN - 0022-1295
VL - 83
SP - 47
EP - 56
JO - Journal of General Physiology
JF - Journal of General Physiology
IS - 1
ER -