TY - JOUR
T1 - Therapeutic developments in pancreatic cancer
AU - Hu, Z. Ian
AU - O’Reilly, Eileen M.
N1 - Publisher Copyright:
© 2023, Springer Nature Limited.
PY - 2024/1
Y1 - 2024/1
N2 - Pancreatic ductal adenocarcinoma (PDAC) has a rising incidence and is one of the most lethal human malignancies. Much is known regarding the biology and pathophysiology of PDAC, but translating this knowledge to the clinic to improve patient outcomes has been challenging. In this Review, we discuss advances and practice-changing trials for PDAC. We briefly review therapeutic failures as well as ongoing research to refine the standard of care, including novel biomarkers and clinical trial designs. In addition, we highlight contemporary areas of research, including poly(ADP-ribose) polymerase inhibitors, KRAS-targeted therapies and immunotherapies. Finally, we discuss the future of pancreatic cancer research and areas for improvement in the next decade.
AB - Pancreatic ductal adenocarcinoma (PDAC) has a rising incidence and is one of the most lethal human malignancies. Much is known regarding the biology and pathophysiology of PDAC, but translating this knowledge to the clinic to improve patient outcomes has been challenging. In this Review, we discuss advances and practice-changing trials for PDAC. We briefly review therapeutic failures as well as ongoing research to refine the standard of care, including novel biomarkers and clinical trial designs. In addition, we highlight contemporary areas of research, including poly(ADP-ribose) polymerase inhibitors, KRAS-targeted therapies and immunotherapies. Finally, we discuss the future of pancreatic cancer research and areas for improvement in the next decade.
UR - http://www.scopus.com/inward/record.url?scp=85173791244&partnerID=8YFLogxK
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U2 - 10.1038/s41575-023-00840-w
DO - 10.1038/s41575-023-00840-w
M3 - Review article
C2 - 37798442
AN - SCOPUS:85173791244
SN - 1759-5045
VL - 21
SP - 7
EP - 24
JO - Nature Reviews Gastroenterology and Hepatology
JF - Nature Reviews Gastroenterology and Hepatology
IS - 1
ER -