Therapeutic options for patients with advanced islet cell and carcinoid tumors

J. A. Ajani, C. H. Carrasco, N. A. Samaan, S. Wallace

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Carcinoid tumors and islet cell carcinomas account for less than 1% of all malignancies. These tumors differ from others in their ability to synthesize a variety of peptide hormones and in their indolent clinical course. Unregulated secretion of pharmacologic quantities of peptides can result in puzzling but debilitating clinical syndromes. The initial diagnosis is often delayed and difficult, because patients present with conglomeration of clinical symptoms that are not uncommonly considered nonspecific and treated symptomatically. Localized tumors are best treated by surgical excision, when feasible, as it remains the most effective method of cure. However, for patients with advanced symptomatic tumors, a number of systemic and regional therapeutic options exist. Recently developed therapeutic agents and treatment methods for these tumors are exciting and mean hope for investigators and patients alike. The currently available therapeutic options are summarized in this paper.

Original languageEnglish (US)
Pages (from-to)235-242
Number of pages8
JournalRegional Cancer Treatment
Volume3
Issue number5
StatePublished - 1991

ASJC Scopus subject areas

  • Oncology
  • Pharmacology

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