Therapy of relapsed or refractory low-grade follicular lymphomas: Factors associated with complete remission, survival and time to treatment failure

J. A. Spinolo; F. Cabanillas; D. O. Dixon; S. M. Khorana; P. Mclaughlin; W. S. Velasquez; F. B. Hagemeister; J. R. Redman; F. Swan

doi:10.1093/oxfordjournals.annonc.a058157

Therapy of relapsed or refractory low-grade follicular lymphomas: Factors associated with complete remission, survival and time to treatment failure

J. A. Spinolo, F. Cabanillas, D. O. Dixon, S. M. Khorana, P. Mclaughlin, W. S. Velasquez, F. B. Hagemeister, J. R. Redman, F. Swan

Lymphoma-Myeloma

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Abstract

Patients with relapsed low-grade follicular lymphomas (LGFL) frequently respond to subsequent therapy and can have long survival, but are rarely cured. Factors associated with complete remission (CR) rate, length of survival, and time to treatment failure (TTF) after relapse are not well known. We assessed such factors by multivariate analysis in a retrospective review of 95 patients with relapsed LGFL treated with investigational chemotherapy regimens at our institution. The CR rate after therapy was 22%; the likelihood of achieving CR was inversely associated with the number of previous treatment failures (P < 0.001) and serum.

Original language	English (US)
Pages (from-to)	227-232
Number of pages	6
Journal	Annals of Oncology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1093/oxfordjournals.annonc.a058157
State	Published - Mar 1992

ASJC Scopus subject areas

Hematology
Oncology

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Spinolo, J. A., Cabanillas, F., Dixon, D. O., Khorana, S. M., Mclaughlin, P., Velasquez, W. S., Hagemeister, F. B., Redman, J. R., & Swan, F. (1992). Therapy of relapsed or refractory low-grade follicular lymphomas: Factors associated with complete remission, survival and time to treatment failure. Annals of Oncology, 3(3), 227-232. https://doi.org/10.1093/oxfordjournals.annonc.a058157

Spinolo, JA, Cabanillas, F, Dixon, DO, Khorana, SM, Mclaughlin, P, Velasquez, WS, Hagemeister, FB, Redman, JR & Swan, F 1992, 'Therapy of relapsed or refractory low-grade follicular lymphomas: Factors associated with complete remission, survival and time to treatment failure', Annals of Oncology, vol. 3, no. 3, pp. 227-232. https://doi.org/10.1093/oxfordjournals.annonc.a058157

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abstract = "Patients with relapsed low-grade follicular lymphomas (LGFL) frequently respond to subsequent therapy and can have long survival, but are rarely cured. Factors associated with complete remission (CR) rate, length of survival, and time to treatment failure (TTF) after relapse are not well known. We assessed such factors by multivariate analysis in a retrospective review of 95 patients with relapsed LGFL treated with investigational chemotherapy regimens at our institution. The CR rate after therapy was 22%; the likelihood of achieving CR was inversely associated with the number of previous treatment failures (P < 0.001) and serum.",

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AU - Khorana, S. M.

AU - Mclaughlin, P.

AU - Velasquez, W. S.

AU - Hagemeister, F. B.

AU - Redman, J. R.

AU - Swan, F.

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Therapy of relapsed or refractory low-grade follicular lymphomas: Factors associated with complete remission, survival and time to treatment failure

Abstract

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