TY - JOUR
T1 - Thioredoxin signaling as a target for cancer therapy
AU - Powis, Garth
AU - Kirkpatrick, D. Lynn
N1 - Funding Information:
The work is supported by NIH Grant CA77204.
PY - 2007/8
Y1 - 2007/8
N2 - Thioredoxin (Trx) family members play critical roles in the regulation of cellular redox homeostasis. Cancer cells exist in a stressed environment and rely on the Trxs for protection against stress-disregulated redox signaling. The most extensively studied member of the family is Trx-1 whose levels are increased in many human cancers most likely in direct response to stress. Trx-1 contributes to many of the hallmarks of cancer including increased proliferation, resistance to cell death and increased angiogenesis. Trx-1 is a validated cancer drug target associated with aggressive tumor growth, resistance to standard therapy and decreased patient survival. A surrogate target for Trx-1 may be thioredoxin reductase (TR). Drugs that inhibit Trx-1 and TR are in clinical development with early promising results.
AB - Thioredoxin (Trx) family members play critical roles in the regulation of cellular redox homeostasis. Cancer cells exist in a stressed environment and rely on the Trxs for protection against stress-disregulated redox signaling. The most extensively studied member of the family is Trx-1 whose levels are increased in many human cancers most likely in direct response to stress. Trx-1 contributes to many of the hallmarks of cancer including increased proliferation, resistance to cell death and increased angiogenesis. Trx-1 is a validated cancer drug target associated with aggressive tumor growth, resistance to standard therapy and decreased patient survival. A surrogate target for Trx-1 may be thioredoxin reductase (TR). Drugs that inhibit Trx-1 and TR are in clinical development with early promising results.
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U2 - 10.1016/j.coph.2007.04.003
DO - 10.1016/j.coph.2007.04.003
M3 - Review article
C2 - 17611157
AN - SCOPUS:34548067718
SN - 1471-4892
VL - 7
SP - 392
EP - 397
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 4
ER -