Thirty-two novel HLA-A alleles identified during intermediate resolution testing

A. M. Lazaro; Y. Xiao; K. Cao; C. Masaberg; L. Nichol; J. Ng; C. K. Hurley; P. E. Posch

doi:10.1111/j.1399-0039.2007.00977.x

Thirty-two novel HLA-A alleles identified during intermediate resolution testing

A. M. Lazaro, Y. Xiao, K. Cao, C. Masaberg, L. Nichol, J. Ng, C. K. Hurley, P. E. Posch

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Thirty-two novel human leukocyte antigen-A alleles are described: four A*01 (*0110, *0112, *0113 and *0117), four A*02 (*0263, *0280, *0292 and *9201), two A*03 (*0316 and *0325), four A*11 (*111502, *1117, *1122 and *1123), five A*24 (*2441, *2450, *2455, *2456 and *2457), one A*26 (*2627), two A*29 (*2909 and *2914), two A*30 (*3013 and *3016), one A*32 (A*3213), two A*34 (*3407 and *3408) and five A*68 (*6828, *6829, *6830, *6831 and *6834). Seventeen of the variants are single-nucleotide substitutions from their most homologous allele, which results in amino acid changes (A*0117, *0263, *0292, *0316, *0325, *1122, *1123, *2455, *2456, *2457, *2627, *2909, *3016, *3407, *6828, *6831 and *6834), and only one is silent substitution (A*111502). The remaining alleles differ from their most similar alleles by two to six nucleotide substitutions.

Original language	English (US)
Pages (from-to)	165-168
Number of pages	4
Journal	Tissue Antigens
Volume	71
Issue number	2
DOIs	https://doi.org/10.1111/j.1399-0039.2007.00977.x
State	Published - Feb 2008
Externally published	Yes

Keywords

DNA sequencing
HLA-A

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Genetics

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10.1111/j.1399-0039.2007.00977.x

Cite this

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title = "Thirty-two novel HLA-A alleles identified during intermediate resolution testing",

abstract = "Thirty-two novel human leukocyte antigen-A alleles are described: four A*01 (*0110, *0112, *0113 and *0117), four A*02 (*0263, *0280, *0292 and *9201), two A*03 (*0316 and *0325), four A*11 (*111502, *1117, *1122 and *1123), five A*24 (*2441, *2450, *2455, *2456 and *2457), one A*26 (*2627), two A*29 (*2909 and *2914), two A*30 (*3013 and *3016), one A*32 (A*3213), two A*34 (*3407 and *3408) and five A*68 (*6828, *6829, *6830, *6831 and *6834). Seventeen of the variants are single-nucleotide substitutions from their most homologous allele, which results in amino acid changes (A*0117, *0263, *0292, *0316, *0325, *1122, *1123, *2455, *2456, *2457, *2627, *2909, *3016, *3407, *6828, *6831 and *6834), and only one is silent substitution (A*111502). The remaining alleles differ from their most similar alleles by two to six nucleotide substitutions.",

keywords = "DNA sequencing, HLA-A",

author = "Lazaro, {A. M.} and Y. Xiao and K. Cao and C. Masaberg and L. Nichol and J. Ng and Hurley, {C. K.} and Posch, {P. E.}",

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T1 - Thirty-two novel HLA-A alleles identified during intermediate resolution testing

AU - Lazaro, A. M.

AU - Xiao, Y.

AU - Cao, K.

AU - Masaberg, C.

AU - Nichol, L.

AU - Ng, J.

AU - Hurley, C. K.

AU - Posch, P. E.

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N2 - Thirty-two novel human leukocyte antigen-A alleles are described: four A*01 (*0110, *0112, *0113 and *0117), four A*02 (*0263, *0280, *0292 and *9201), two A*03 (*0316 and *0325), four A*11 (*111502, *1117, *1122 and *1123), five A*24 (*2441, *2450, *2455, *2456 and *2457), one A*26 (*2627), two A*29 (*2909 and *2914), two A*30 (*3013 and *3016), one A*32 (A*3213), two A*34 (*3407 and *3408) and five A*68 (*6828, *6829, *6830, *6831 and *6834). Seventeen of the variants are single-nucleotide substitutions from their most homologous allele, which results in amino acid changes (A*0117, *0263, *0292, *0316, *0325, *1122, *1123, *2455, *2456, *2457, *2627, *2909, *3016, *3407, *6828, *6831 and *6834), and only one is silent substitution (A*111502). The remaining alleles differ from their most similar alleles by two to six nucleotide substitutions.

AB - Thirty-two novel human leukocyte antigen-A alleles are described: four A*01 (*0110, *0112, *0113 and *0117), four A*02 (*0263, *0280, *0292 and *9201), two A*03 (*0316 and *0325), four A*11 (*111502, *1117, *1122 and *1123), five A*24 (*2441, *2450, *2455, *2456 and *2457), one A*26 (*2627), two A*29 (*2909 and *2914), two A*30 (*3013 and *3016), one A*32 (A*3213), two A*34 (*3407 and *3408) and five A*68 (*6828, *6829, *6830, *6831 and *6834). Seventeen of the variants are single-nucleotide substitutions from their most homologous allele, which results in amino acid changes (A*0117, *0263, *0292, *0316, *0325, *1122, *1123, *2455, *2456, *2457, *2627, *2909, *3016, *3407, *6828, *6831 and *6834), and only one is silent substitution (A*111502). The remaining alleles differ from their most similar alleles by two to six nucleotide substitutions.

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Thirty-two novel HLA-A alleles identified during intermediate resolution testing

Abstract

Keywords

ASJC Scopus subject areas

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