Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer

Mona Kamal; Sweet Ping Ng; Salman A. Eraj; Crosby D. Rock; Brian Pham; Jay A. Messer; Adam S. Garden; William H. Morrison; Jack Phan; Steven J. Frank; Adel K. El-Naggar; Jason M. Johnson; Lawrence E. Ginsberg; Renata Ferrarotto; Jan S. Lewin; Katherine A. Hutcheson; Carlos E. Cardenas; Mark E. Zafereo; Stephen Y. Lai; Amy C. Hessel; Randal S. Weber; G. Brandon Gunn; Clifton D. Fuller; Abdallah S.R. Mohamed; David I. Rosenthal

doi:10.1016/j.oraloncology.2018.01.025

Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer

Mona Kamal, Sweet Ping Ng, Salman A. Eraj, Crosby D. Rock, Brian Pham, Jay A. Messer, Adam S. Garden, William H. Morrison, Jack Phan, Steven J. Frank, Adel K. El-Naggar, Jason M. Johnson, Lawrence E. Ginsberg, Renata Ferrarotto, Jan S. Lewin, Katherine A. Hutcheson, Carlos E. Cardenas, Mark E. Zafereo, Stephen Y. Lai, Amy C. HesselRandal S. Weber, G. Brandon Gunn, Clifton D. Fuller, Abdallah S.R. Mohamed, David I. Rosenthal

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objectives: To investigate the impact of 3-Diminsional (3D) tumor volume (TV) and extent of involvement of primary tumor on treatment outcomes in a large uniform cohort of T3 laryngeal carcinoma patients treated with nonsurgical laryngeal preservation strategies. Materials and Methods: The pretreatment contrast-enhanced computed tomography images of 90 patients with T3 laryngeal carcinoma were reviewed. Primary gross tumor volume (GTVp) was delineated to calculate the 3D TV and define the extent of invasion. Cartilage and soft tissue involvement was coded. The extent of invasion was dichotomized into non/limited invasion versus multiple invasion extension (MIE), and was subsequently correlated with survival outcomes. Results: The median TV was 6.6 cm ³ . Sixty-five patients had non/limited invasion, and 25 had MIE. Median follow-up for surviving patients was 52 months. The 5-year local control and overall survival rates for the whole cohort were 88% and 68%, respectively. There was no correlation between TV and survival outcomes. However, patients with non/limited invasion had better 5-year local control (LC) than those with MIE (95% vs 72%, p =.009) but did not have a significantly higher rate of overall survival (OS) (74% vs 67%, p =.327). In multivariate correlates of LC, MIE maintained statistical significance whereas baseline airway status showed a statistically significance trend with poor LC (p =.0087 and 0.06, respectively). Baseline good performance status was an independent predictor of improved OS (p =.03) in multivariate analysis. Conclusion: The extent of primary tumor invasion is an independent prognostic factor of LC of the disease after definitive radiotherapy in T3 larynx cancer.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Oral Oncology
Volume	79
DOIs	https://doi.org/10.1016/j.oraloncology.2018.01.025
State	Published - Apr 2018

Keywords

Chemoradiotherapy
Laryngeal preservation
Radiation therapy
T3 laryngeal cancer
Tumor volume

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

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10.1016/j.oraloncology.2018.01.025

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Kamal, M., Ng, S. P., Eraj, S. A., Rock, C. D., Pham, B., Messer, J. A., Garden, A. S., Morrison, W. H., Phan, J., Frank, S. J., El-Naggar, A. K., Johnson, J. M., Ginsberg, L. E., Ferrarotto, R., Lewin, J. S., Hutcheson, K. A., Cardenas, C. E., Zafereo, M. E., Lai, S. Y., ... Rosenthal, D. I. (2018). Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer. Oral Oncology, 79, 1-8. https://doi.org/10.1016/j.oraloncology.2018.01.025

Kamal, M, Ng, SP, Eraj, SA, Rock, CD, Pham, B, Messer, JA, Garden, AS , Morrison, WH , Phan, J , Frank, SJ , El-Naggar, AK, Johnson, JM, Ginsberg, LE, Ferrarotto, R, Lewin, JS, Hutcheson, KA, Cardenas, CE, Zafereo, ME , Lai, SY , Hessel, AC, Weber, RS, Gunn, GB , Fuller, CD , Mohamed, ASR & Rosenthal, DI 2018, 'Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer', Oral Oncology, vol. 79, pp. 1-8. https://doi.org/10.1016/j.oraloncology.2018.01.025

@article{2879db2a6bc5445b855582ac67f38d09,

title = "Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer",

abstract = " Objectives: To investigate the impact of 3-Diminsional (3D) tumor volume (TV) and extent of involvement of primary tumor on treatment outcomes in a large uniform cohort of T3 laryngeal carcinoma patients treated with nonsurgical laryngeal preservation strategies. Materials and Methods: The pretreatment contrast-enhanced computed tomography images of 90 patients with T3 laryngeal carcinoma were reviewed. Primary gross tumor volume (GTVp) was delineated to calculate the 3D TV and define the extent of invasion. Cartilage and soft tissue involvement was coded. The extent of invasion was dichotomized into non/limited invasion versus multiple invasion extension (MIE), and was subsequently correlated with survival outcomes. Results: The median TV was 6.6 cm 3 . Sixty-five patients had non/limited invasion, and 25 had MIE. Median follow-up for surviving patients was 52 months. The 5-year local control and overall survival rates for the whole cohort were 88% and 68%, respectively. There was no correlation between TV and survival outcomes. However, patients with non/limited invasion had better 5-year local control (LC) than those with MIE (95% vs 72%, p =.009) but did not have a significantly higher rate of overall survival (OS) (74% vs 67%, p =.327). In multivariate correlates of LC, MIE maintained statistical significance whereas baseline airway status showed a statistically significance trend with poor LC (p =.0087 and 0.06, respectively). Baseline good performance status was an independent predictor of improved OS (p =.03) in multivariate analysis. Conclusion: The extent of primary tumor invasion is an independent prognostic factor of LC of the disease after definitive radiotherapy in T3 larynx cancer.",

keywords = "Chemoradiotherapy, Laryngeal preservation, Radiation therapy, T3 laryngeal cancer, Tumor volume",

author = "Mona Kamal and Ng, {Sweet Ping} and Eraj, {Salman A.} and Rock, {Crosby D.} and Brian Pham and Messer, {Jay A.} and Garden, {Adam S.} and Morrison, {William H.} and Jack Phan and Frank, {Steven J.} and El-Naggar, {Adel K.} and Johnson, {Jason M.} and Ginsberg, {Lawrence E.} and Renata Ferrarotto and Lewin, {Jan S.} and Hutcheson, {Katherine A.} and Cardenas, {Carlos E.} and Zafereo, {Mark E.} and Lai, {Stephen Y.} and Hessel, {Amy C.} and Weber, {Randal S.} and Gunn, {G. Brandon} and Fuller, {Clifton D.} and Mohamed, {Abdallah S.R.} and Rosenthal, {David I.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = apr,

doi = "10.1016/j.oraloncology.2018.01.025",

language = "English (US)",

volume = "79",

pages = "1--8",

journal = "Oral Oncology",

issn = "1368-8375",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer

AU - Kamal, Mona

AU - Ng, Sweet Ping

AU - Eraj, Salman A.

AU - Rock, Crosby D.

AU - Pham, Brian

AU - Messer, Jay A.

AU - Garden, Adam S.

AU - Morrison, William H.

AU - Phan, Jack

AU - Frank, Steven J.

AU - El-Naggar, Adel K.

AU - Johnson, Jason M.

AU - Ginsberg, Lawrence E.

AU - Ferrarotto, Renata

AU - Lewin, Jan S.

AU - Hutcheson, Katherine A.

AU - Cardenas, Carlos E.

AU - Zafereo, Mark E.

AU - Lai, Stephen Y.

AU - Hessel, Amy C.

AU - Weber, Randal S.

AU - Gunn, G. Brandon

AU - Fuller, Clifton D.

AU - Mohamed, Abdallah S.R.

AU - Rosenthal, David I.

PY - 2018/4

Y1 - 2018/4

N2 - Objectives: To investigate the impact of 3-Diminsional (3D) tumor volume (TV) and extent of involvement of primary tumor on treatment outcomes in a large uniform cohort of T3 laryngeal carcinoma patients treated with nonsurgical laryngeal preservation strategies. Materials and Methods: The pretreatment contrast-enhanced computed tomography images of 90 patients with T3 laryngeal carcinoma were reviewed. Primary gross tumor volume (GTVp) was delineated to calculate the 3D TV and define the extent of invasion. Cartilage and soft tissue involvement was coded. The extent of invasion was dichotomized into non/limited invasion versus multiple invasion extension (MIE), and was subsequently correlated with survival outcomes. Results: The median TV was 6.6 cm 3 . Sixty-five patients had non/limited invasion, and 25 had MIE. Median follow-up for surviving patients was 52 months. The 5-year local control and overall survival rates for the whole cohort were 88% and 68%, respectively. There was no correlation between TV and survival outcomes. However, patients with non/limited invasion had better 5-year local control (LC) than those with MIE (95% vs 72%, p =.009) but did not have a significantly higher rate of overall survival (OS) (74% vs 67%, p =.327). In multivariate correlates of LC, MIE maintained statistical significance whereas baseline airway status showed a statistically significance trend with poor LC (p =.0087 and 0.06, respectively). Baseline good performance status was an independent predictor of improved OS (p =.03) in multivariate analysis. Conclusion: The extent of primary tumor invasion is an independent prognostic factor of LC of the disease after definitive radiotherapy in T3 larynx cancer.

AB - Objectives: To investigate the impact of 3-Diminsional (3D) tumor volume (TV) and extent of involvement of primary tumor on treatment outcomes in a large uniform cohort of T3 laryngeal carcinoma patients treated with nonsurgical laryngeal preservation strategies. Materials and Methods: The pretreatment contrast-enhanced computed tomography images of 90 patients with T3 laryngeal carcinoma were reviewed. Primary gross tumor volume (GTVp) was delineated to calculate the 3D TV and define the extent of invasion. Cartilage and soft tissue involvement was coded. The extent of invasion was dichotomized into non/limited invasion versus multiple invasion extension (MIE), and was subsequently correlated with survival outcomes. Results: The median TV was 6.6 cm 3 . Sixty-five patients had non/limited invasion, and 25 had MIE. Median follow-up for surviving patients was 52 months. The 5-year local control and overall survival rates for the whole cohort were 88% and 68%, respectively. There was no correlation between TV and survival outcomes. However, patients with non/limited invasion had better 5-year local control (LC) than those with MIE (95% vs 72%, p =.009) but did not have a significantly higher rate of overall survival (OS) (74% vs 67%, p =.327). In multivariate correlates of LC, MIE maintained statistical significance whereas baseline airway status showed a statistically significance trend with poor LC (p =.0087 and 0.06, respectively). Baseline good performance status was an independent predictor of improved OS (p =.03) in multivariate analysis. Conclusion: The extent of primary tumor invasion is an independent prognostic factor of LC of the disease after definitive radiotherapy in T3 larynx cancer.

KW - Chemoradiotherapy

KW - Laryngeal preservation

KW - Radiation therapy

KW - T3 laryngeal cancer

KW - Tumor volume

UR - http://www.scopus.com/inward/record.url?scp=85041705089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041705089&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2018.01.025

DO - 10.1016/j.oraloncology.2018.01.025

M3 - Article

C2 - 29598944

AN - SCOPUS:85041705089

SN - 1368-8375

VL - 79

SP - 1

EP - 8

JO - Oral Oncology

JF - Oral Oncology

ER -

Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer

Abstract

Keywords

ASJC Scopus subject areas

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