TY - JOUR
T1 - Three-Dimensional Quantitative Color-Coding Analysis of Hepatic Arterial Flow Change during Chemoembolization of Hepatocellular Carcinoma
AU - Lin, Ethan Yiyang
AU - Lee, Rheun Chuan
AU - Guo, Wan Yuo
AU - Wu, Frank Chun Hsien
AU - Gehrisch, Sonja
AU - Kowarschik, Markus
N1 - Funding Information:
This research was supported by Taipei Veterans General Hospital and Siemens Healthcare (grant no. T1100200).
Publisher Copyright:
© 2018 SIR
PY - 2018/10
Y1 - 2018/10
N2 - Purpose: To evaluate feasibility of using three-dimensional (3D) quantitative color-coding analysis (QCA) to quantify substasis endpoints after transcatheter arterial chemoembolization of hepatocellular carcinoma (HCC). Materials and Methods: This single-institution prospective study included 20 patients with HCC who had undergone segmental or subsegmental transcatheter arterial chemoembolization between December 2015 and March 2017. The chemoembolization endpoint was a sluggish anterograde tumor-feeding arterial flow without residual tumor stains. Contrast medium bolus arrival time (BAT) was used as an indicator of arterial flow. BAT of the proper hepatic artery was obtained as a reference point. BATs of the proximal right lobar artery, proximal left lobar artery, and segmental artery that received embolization were analyzed before and after chemoembolization. Wilcoxon signed rank test was used to evaluate the difference between BATs before and after chemoembolization. Results: BATs before and after chemoembolization of the segmental artery that received embolization were 0.47 seconds (interquartile range [IQR], 0.31–0.70 s) and 1.04 seconds (IQR, 0.78–2.01 s; P <.001), respectively. BATs before and after chemoembolization of the proximal left lobar hepatic artery (0.35 s [IQR, 0.11–0.55] and 0.13 s [IQR, 0.05–0.32], P =.025) and right lobar hepatic artery (0.23 s [IQR, 0.13–0.65] and 0.22 s [IQR, 0.08–0.39], P =.027) exhibited no significant change. Conclusions: 3D QCA is a feasible method for quantifying sluggish segmental arterial flow after transcatheter arterial chemoembolization in patients with HCC.
AB - Purpose: To evaluate feasibility of using three-dimensional (3D) quantitative color-coding analysis (QCA) to quantify substasis endpoints after transcatheter arterial chemoembolization of hepatocellular carcinoma (HCC). Materials and Methods: This single-institution prospective study included 20 patients with HCC who had undergone segmental or subsegmental transcatheter arterial chemoembolization between December 2015 and March 2017. The chemoembolization endpoint was a sluggish anterograde tumor-feeding arterial flow without residual tumor stains. Contrast medium bolus arrival time (BAT) was used as an indicator of arterial flow. BAT of the proper hepatic artery was obtained as a reference point. BATs of the proximal right lobar artery, proximal left lobar artery, and segmental artery that received embolization were analyzed before and after chemoembolization. Wilcoxon signed rank test was used to evaluate the difference between BATs before and after chemoembolization. Results: BATs before and after chemoembolization of the segmental artery that received embolization were 0.47 seconds (interquartile range [IQR], 0.31–0.70 s) and 1.04 seconds (IQR, 0.78–2.01 s; P <.001), respectively. BATs before and after chemoembolization of the proximal left lobar hepatic artery (0.35 s [IQR, 0.11–0.55] and 0.13 s [IQR, 0.05–0.32], P =.025) and right lobar hepatic artery (0.23 s [IQR, 0.13–0.65] and 0.22 s [IQR, 0.08–0.39], P =.027) exhibited no significant change. Conclusions: 3D QCA is a feasible method for quantifying sluggish segmental arterial flow after transcatheter arterial chemoembolization in patients with HCC.
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U2 - 10.1016/j.jvir.2018.04.012
DO - 10.1016/j.jvir.2018.04.012
M3 - Article
C2 - 30170947
AN - SCOPUS:85052745036
SN - 1051-0443
VL - 29
SP - 1362
EP - 1368
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 10
ER -