TY - JOUR
T1 - Thymic hyperplasia with lymphoepithelial sialadenitis (LESA)-Like features
T2 - A clinicopathologic and immunohistochemical study of 4 cases
AU - Weissferdt, Annikka
AU - Moran, Cesar A.
PY - 2012/12
Y1 - 2012/12
N2 - Four cases of an unusual type of thymic hyperplasia strongly resembling lymphoepithelial sialadenitis (LESA) of the salivary glands are described. The patients were 2 men and 2 women aged 37 to 53 years. On histologic examination, abundant lymphoid tissue with lymphoid follicles containing germinal centers and areas of plasma cell infiltration were seen. The epithelial component consisted of a proliferation of Hassall corpuscles and islands of thymic epithelial cells. Cystic changes and lymphoepithelial lesions were identified in all cases, but a monocytoid B-cell population was absent. On immunohistochemical examination, a mixed B- and T-cell population was identified, and polymerase chain reaction performed in 1 case showed polyclonality. Follow-up revealed that all patients were alive 5 months to 9 years after diagnosis. The cases in this series represent a distinct type of thymic hyperplasia that histologically strongly resembles LESA. The clinicopathologic and immunohistochemical features are presented, and a possible relationship with thymic mucosa-associated lymphoid tissue (MALT) lymphoma is discussed.
AB - Four cases of an unusual type of thymic hyperplasia strongly resembling lymphoepithelial sialadenitis (LESA) of the salivary glands are described. The patients were 2 men and 2 women aged 37 to 53 years. On histologic examination, abundant lymphoid tissue with lymphoid follicles containing germinal centers and areas of plasma cell infiltration were seen. The epithelial component consisted of a proliferation of Hassall corpuscles and islands of thymic epithelial cells. Cystic changes and lymphoepithelial lesions were identified in all cases, but a monocytoid B-cell population was absent. On immunohistochemical examination, a mixed B- and T-cell population was identified, and polymerase chain reaction performed in 1 case showed polyclonality. Follow-up revealed that all patients were alive 5 months to 9 years after diagnosis. The cases in this series represent a distinct type of thymic hyperplasia that histologically strongly resembles LESA. The clinicopathologic and immunohistochemical features are presented, and a possible relationship with thymic mucosa-associated lymphoid tissue (MALT) lymphoma is discussed.
KW - Lymphoepithelial sialadenitis (LESA)
KW - Lymphoid hyperplasia
KW - MALT lymphoma
KW - Thymus
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U2 - 10.1309/AJCPM6W5MHZMUZRS
DO - 10.1309/AJCPM6W5MHZMUZRS
M3 - Article
C2 - 23161715
AN - SCOPUS:84869228913
SN - 0002-9173
VL - 138
SP - 816
EP - 822
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 6
ER -