Thyrotropin releasing hormone in the pancreas of newborn rats from streptozotocin - Treated mothers

V. Štrbák; L. H. Ouafik; E. Rešetková; C. Oliver; P. Giraud; A. Dutour; P. Salers; A. Randušková

doi:10.1016/0024-3205(89)90375-5

Thyrotropin releasing hormone in the pancreas of newborn rats from streptozotocin - Treated mothers

V. Štrbák, L. H. Ouafik, E. Rešetková, C. Oliver, P. Giraud, A. Dutour, P. Salers, A. Randušková

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The effect of maternal diabetes (induced by i.p.injections of 40-50 mg/kg BW Streptozotocin on the day of mating) on TRH in the pancreas of newborn rats was studied. Determination of peptide alpha amidation activity and TRH precursor level on the day of birth revealed decreased biosynthesis of TRH resulting in profoundly (10 times) lower pancreatic TRH and TRH-OH concentrations in pups of diabetic rats. Pancreatic His-Pro-diketopiperazine (His-Pro-DKP) remained unaffected by maternal diabetes. The depression of pancreatic TRH was less profound 24 h later, and even elevated TRH was measured in the pancreas of pups of diabetic mothers on postnatal day 5. Short term postnatal starvation or nursing of intact pups by the diabetic foster mother did not affect pancreatic TRH. It could be postulated that postnatal TRH development in the rat pancreas is retarded by maternal diabetes, while His-Pro-DKP remains unaltered.

Original language	English (US)
Pages (from-to)	779-787
Number of pages	9
Journal	Life Sciences
Volume	44
Issue number	12
DOIs	https://doi.org/10.1016/0024-3205(89)90375-5
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(89)90375-5

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@article{d39104d4605346a6b5906408a88a275d,

title = "Thyrotropin releasing hormone in the pancreas of newborn rats from streptozotocin - Treated mothers",

abstract = "The effect of maternal diabetes (induced by i.p.injections of 40-50 mg/kg BW Streptozotocin on the day of mating) on TRH in the pancreas of newborn rats was studied. Determination of peptide alpha amidation activity and TRH precursor level on the day of birth revealed decreased biosynthesis of TRH resulting in profoundly (10 times) lower pancreatic TRH and TRH-OH concentrations in pups of diabetic rats. Pancreatic His-Pro-diketopiperazine (His-Pro-DKP) remained unaffected by maternal diabetes. The depression of pancreatic TRH was less profound 24 h later, and even elevated TRH was measured in the pancreas of pups of diabetic mothers on postnatal day 5. Short term postnatal starvation or nursing of intact pups by the diabetic foster mother did not affect pancreatic TRH. It could be postulated that postnatal TRH development in the rat pancreas is retarded by maternal diabetes, while His-Pro-DKP remains unaltered.",

author = "V. {\v S}trb{\'a}k and Ouafik, {L. H.} and E. Re{\v s}etkov{\'a} and C. Oliver and P. Giraud and A. Dutour and P. Salers and A. Randu{\v s}kov{\'a}",

note = "Funding Information: The present work was supported by the Slovak Academy of Sciences and by grants from INSERM and University of Medicine (Marseille). The authors would like to thank Or. E.Kasafirek (VUFB Prague) preparing synthetic TRH.",

year = "1989",

doi = "10.1016/0024-3205(89)90375-5",

language = "English (US)",

volume = "44",

pages = "779--787",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "12",

}

TY - JOUR

T1 - Thyrotropin releasing hormone in the pancreas of newborn rats from streptozotocin - Treated mothers

AU - Štrbák, V.

AU - Ouafik, L. H.

AU - Rešetková, E.

AU - Oliver, C.

AU - Giraud, P.

AU - Dutour, A.

AU - Salers, P.

AU - Randušková, A.

N1 - Funding Information: The present work was supported by the Slovak Academy of Sciences and by grants from INSERM and University of Medicine (Marseille). The authors would like to thank Or. E.Kasafirek (VUFB Prague) preparing synthetic TRH.

PY - 1989

Y1 - 1989

N2 - The effect of maternal diabetes (induced by i.p.injections of 40-50 mg/kg BW Streptozotocin on the day of mating) on TRH in the pancreas of newborn rats was studied. Determination of peptide alpha amidation activity and TRH precursor level on the day of birth revealed decreased biosynthesis of TRH resulting in profoundly (10 times) lower pancreatic TRH and TRH-OH concentrations in pups of diabetic rats. Pancreatic His-Pro-diketopiperazine (His-Pro-DKP) remained unaffected by maternal diabetes. The depression of pancreatic TRH was less profound 24 h later, and even elevated TRH was measured in the pancreas of pups of diabetic mothers on postnatal day 5. Short term postnatal starvation or nursing of intact pups by the diabetic foster mother did not affect pancreatic TRH. It could be postulated that postnatal TRH development in the rat pancreas is retarded by maternal diabetes, while His-Pro-DKP remains unaltered.

AB - The effect of maternal diabetes (induced by i.p.injections of 40-50 mg/kg BW Streptozotocin on the day of mating) on TRH in the pancreas of newborn rats was studied. Determination of peptide alpha amidation activity and TRH precursor level on the day of birth revealed decreased biosynthesis of TRH resulting in profoundly (10 times) lower pancreatic TRH and TRH-OH concentrations in pups of diabetic rats. Pancreatic His-Pro-diketopiperazine (His-Pro-DKP) remained unaffected by maternal diabetes. The depression of pancreatic TRH was less profound 24 h later, and even elevated TRH was measured in the pancreas of pups of diabetic mothers on postnatal day 5. Short term postnatal starvation or nursing of intact pups by the diabetic foster mother did not affect pancreatic TRH. It could be postulated that postnatal TRH development in the rat pancreas is retarded by maternal diabetes, while His-Pro-DKP remains unaltered.

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IS - 12

ER -

Thyrotropin releasing hormone in the pancreas of newborn rats from streptozotocin - Treated mothers

Abstract

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