Time and PSA threshold model prognosticates long-term overall and disease-specific survival in prostate cancer patients as early as 3 months after external beam radiation therapy

Sean X. Cavanaugh; C. D. Fuller; P. A. Kupelian; C. Reddy; P. Bradshaw; B. H. Pollock; M. Fuss

doi:10.1038/sj.pcan.4500831

Time and PSA threshold model prognosticates long-term overall and disease-specific survival in prostate cancer patients as early as 3 months after external beam radiation therapy

Sean X. Cavanaugh, C. D. Fuller, P. A. Kupelian, C. Reddy, P. Bradshaw, B. H. Pollock, M. Fuss

Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

The specific aim of this analysis was to evaluate the capability of a time and prostate-specific antigen (PSA) threshold model to prognosticate overall survival (OS) and disease-specific survival (DSS) based on early PSA kinetics after radiotherapy for prostate cancer by retrospective review of outcomes in 918 patients. Crossing below analyzed PSA thresholds at specific defined time points reduced disease-specific death hazard ratios to relative to the cohort above threshold. The time and PSA threshold model demonstrates the ability to prognosticate OS and DSS as early as 3 months post-radiotherapy for prostate cancer.

Original language	English (US)
Pages (from-to)	353-358
Number of pages	6
Journal	Prostate Cancer and Prostatic Diseases
Volume	8
Issue number	4
DOIs	https://doi.org/10.1038/sj.pcan.4500831
State	Published - Dec 2005

Keywords

Prognostic
Radiotherapy
Survival
Threshold
Time

ASJC Scopus subject areas

Oncology
Urology
Cancer Research

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10.1038/sj.pcan.4500831

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Cavanaugh, S. X., Fuller, C. D., Kupelian, P. A., Reddy, C., Bradshaw, P., Pollock, B. H., & Fuss, M. (2005). Time and PSA threshold model prognosticates long-term overall and disease-specific survival in prostate cancer patients as early as 3 months after external beam radiation therapy. Prostate Cancer and Prostatic Diseases, 8(4), 353-358. https://doi.org/10.1038/sj.pcan.4500831

Time and PSA threshold model prognosticates long-term overall and disease-specific survival in prostate cancer patients as early as 3 months after external beam radiation therapy. / Cavanaugh, Sean X.; Fuller, C. D.; Kupelian, P. A. et al.
In: Prostate Cancer and Prostatic Diseases, Vol. 8, No. 4, 12.2005, p. 353-358.

Research output: Contribution to journal › Review article › peer-review

Cavanaugh, SX, Fuller, CD, Kupelian, PA, Reddy, C, Bradshaw, P, Pollock, BH & Fuss, M 2005, 'Time and PSA threshold model prognosticates long-term overall and disease-specific survival in prostate cancer patients as early as 3 months after external beam radiation therapy', Prostate Cancer and Prostatic Diseases, vol. 8, no. 4, pp. 353-358. https://doi.org/10.1038/sj.pcan.4500831

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abstract = "The specific aim of this analysis was to evaluate the capability of a time and prostate-specific antigen (PSA) threshold model to prognosticate overall survival (OS) and disease-specific survival (DSS) based on early PSA kinetics after radiotherapy for prostate cancer by retrospective review of outcomes in 918 patients. Crossing below analyzed PSA thresholds at specific defined time points reduced disease-specific death hazard ratios to relative to the cohort above threshold. The time and PSA threshold model demonstrates the ability to prognosticate OS and DSS as early as 3 months post-radiotherapy for prostate cancer.",

keywords = "Prognostic, Radiotherapy, Survival, Threshold, Time",

author = "Cavanaugh, {Sean X.} and Fuller, {C. D.} and Kupelian, {P. A.} and C. Reddy and P. Bradshaw and Pollock, {B. H.} and M. Fuss",

note = "Funding Information: Mr Fuller was supported by a grant from the NIH/ NCRR/Frederic C Bartter GCRC-Mentored Medical Student Clinical Research Program (NIH M01-RR01346). Preliminary data from this work were presented at the meeting of the German Society for Radiation Oncology (DEGRO), in Erfurt, Germany, June 2004.",

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doi = "10.1038/sj.pcan.4500831",

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AU - Reddy, C.

AU - Bradshaw, P.

AU - Pollock, B. H.

AU - Fuss, M.

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N2 - The specific aim of this analysis was to evaluate the capability of a time and prostate-specific antigen (PSA) threshold model to prognosticate overall survival (OS) and disease-specific survival (DSS) based on early PSA kinetics after radiotherapy for prostate cancer by retrospective review of outcomes in 918 patients. Crossing below analyzed PSA thresholds at specific defined time points reduced disease-specific death hazard ratios to relative to the cohort above threshold. The time and PSA threshold model demonstrates the ability to prognosticate OS and DSS as early as 3 months post-radiotherapy for prostate cancer.

AB - The specific aim of this analysis was to evaluate the capability of a time and prostate-specific antigen (PSA) threshold model to prognosticate overall survival (OS) and disease-specific survival (DSS) based on early PSA kinetics after radiotherapy for prostate cancer by retrospective review of outcomes in 918 patients. Crossing below analyzed PSA thresholds at specific defined time points reduced disease-specific death hazard ratios to relative to the cohort above threshold. The time and PSA threshold model demonstrates the ability to prognosticate OS and DSS as early as 3 months post-radiotherapy for prostate cancer.

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KW - Radiotherapy

KW - Survival

KW - Threshold

KW - Time

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Time and PSA threshold model prognosticates long-term overall and disease-specific survival in prostate cancer patients as early as 3 months after external beam radiation therapy

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