TY - JOUR
T1 - Time course for the hazard of radiation-induced pneumonitis death in mice
AU - Tucker, S. L.
AU - Travis, E. L.
N1 - Funding Information:
This work was supported in part by grants CA-11430, CA-48672, CA-16672, CA-38106 and CA-06924 from the National Cancer Institute, The National Institutes of Health .
PY - 1992
Y1 - 1992
N2 - The form of the hazard function for radiation-induced pneumonitis death in mice was investigated. Hazard refers to the instantaneous failure rate at a specified time, conditional upon non-failure to that time. Thus, the hazard function describes the time profile for the risk of pneumonitis death among still-surviving subjects. Single-dose lethality data from nine previously published studies involving irradiation of the lung were combined. Sufficient data were then available to estimate the hazard for eight different dose groups (dose range 12-15 Gy). The results of this study suggest that there are multiple distinct peaks in the hazard function for radiation pneumonitis, corresponding to distinct waves of death separated by an average interval of 33 days. The times of the peak hazards are dose dependent, with the peak hazards occurring earlier after larger doses, and the values of the hazards at the peaks are also dose dependent, with larger doses corresponding to a greater risk of death. The implications of a multiply-peaked hazard function for the possible mechanisms of response to whole-lung irradiation are discussed.
AB - The form of the hazard function for radiation-induced pneumonitis death in mice was investigated. Hazard refers to the instantaneous failure rate at a specified time, conditional upon non-failure to that time. Thus, the hazard function describes the time profile for the risk of pneumonitis death among still-surviving subjects. Single-dose lethality data from nine previously published studies involving irradiation of the lung were combined. Sufficient data were then available to estimate the hazard for eight different dose groups (dose range 12-15 Gy). The results of this study suggest that there are multiple distinct peaks in the hazard function for radiation pneumonitis, corresponding to distinct waves of death separated by an average interval of 33 days. The times of the peak hazards are dose dependent, with the peak hazards occurring earlier after larger doses, and the values of the hazards at the peaks are also dose dependent, with larger doses corresponding to a greater risk of death. The implications of a multiply-peaked hazard function for the possible mechanisms of response to whole-lung irradiation are discussed.
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U2 - 10.1080/09553009214552551
DO - 10.1080/09553009214552551
M3 - Article
C2 - 1361520
AN - SCOPUS:0026739986
SN - 0955-3002
VL - 62
SP - 627
EP - 639
JO - International journal of radiation biology
JF - International journal of radiation biology
IS - 5
ER -