Tissue specific control of α-fetoprotein gene expression

Gilbert J. Cote; Jen Fu Chiu

doi:10.1016/0006-291X(84)91309-3

Tissue specific control of α-fetoprotein gene expression

Gilbert J. Cote, Jen Fu Chiu

Endocrine Neoplasia & HD

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The expression of the alpha-fetoprotein (AFP) gene was studied in rat liver and kidney. A significant level of AFP mRNA was found in neonatal liver and kidney, but not in adult tissues. Unlike liver the re-expression of AFP mRNA was not seen upon chemically induced regeneration of the kidney. Treatment of neonatal rats with dexamethasone caused a decrease in liver AFP mRNA levels, but a similar decrease was not apparent in kidney. Northern analysis revealed AFP mRNA size to be identical in neonatal liver and kidney. The results suggest different gene regulatory mechanisms in liver and kidney for the AFP gene.

Original language	English (US)
Pages (from-to)	677-685
Number of pages	9
Journal	Biochemical and biophysical research communications
Volume	120
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(84)91309-3
State	Published - Apr 30 1984

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/0006-291X(84)91309-3

Cite this

@article{ab990f52e9ba4e1fb52d3186f9e7b43b,

title = "Tissue specific control of α-fetoprotein gene expression",

abstract = "The expression of the alpha-fetoprotein (AFP) gene was studied in rat liver and kidney. A significant level of AFP mRNA was found in neonatal liver and kidney, but not in adult tissues. Unlike liver the re-expression of AFP mRNA was not seen upon chemically induced regeneration of the kidney. Treatment of neonatal rats with dexamethasone caused a decrease in liver AFP mRNA levels, but a similar decrease was not apparent in kidney. Northern analysis revealed AFP mRNA size to be identical in neonatal liver and kidney. The results suggest different gene regulatory mechanisms in liver and kidney for the AFP gene.",

author = "Cote, {Gilbert J.} and Chiu, {Jen Fu}",

note = "Funding Information: by USPHS Grant",

year = "1984",

month = apr,

day = "30",

doi = "10.1016/0006-291X(84)91309-3",

language = "English (US)",

volume = "120",

pages = "677--685",

journal = "Biochemical and biophysical research communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Tissue specific control of α-fetoprotein gene expression

AU - Cote, Gilbert J.

AU - Chiu, Jen Fu

N1 - Funding Information: by USPHS Grant

PY - 1984/4/30

Y1 - 1984/4/30

N2 - The expression of the alpha-fetoprotein (AFP) gene was studied in rat liver and kidney. A significant level of AFP mRNA was found in neonatal liver and kidney, but not in adult tissues. Unlike liver the re-expression of AFP mRNA was not seen upon chemically induced regeneration of the kidney. Treatment of neonatal rats with dexamethasone caused a decrease in liver AFP mRNA levels, but a similar decrease was not apparent in kidney. Northern analysis revealed AFP mRNA size to be identical in neonatal liver and kidney. The results suggest different gene regulatory mechanisms in liver and kidney for the AFP gene.

AB - The expression of the alpha-fetoprotein (AFP) gene was studied in rat liver and kidney. A significant level of AFP mRNA was found in neonatal liver and kidney, but not in adult tissues. Unlike liver the re-expression of AFP mRNA was not seen upon chemically induced regeneration of the kidney. Treatment of neonatal rats with dexamethasone caused a decrease in liver AFP mRNA levels, but a similar decrease was not apparent in kidney. Northern analysis revealed AFP mRNA size to be identical in neonatal liver and kidney. The results suggest different gene regulatory mechanisms in liver and kidney for the AFP gene.

UR - http://www.scopus.com/inward/record.url?scp=0021235566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021235566&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(84)91309-3

DO - 10.1016/0006-291X(84)91309-3

M3 - Article

C2 - 6203525

AN - SCOPUS:0021235566

SN - 0006-291X

VL - 120

SP - 677

EP - 685

JO - Biochemical and biophysical research communications

JF - Biochemical and biophysical research communications

IS - 2

ER -

Tissue specific control of α-fetoprotein gene expression

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this