Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2

Arya Biragyn; Pier Adelchi Ruffini; Cynthia A. Leifer; Elena Klyushnenkova; Alexander Shakhov; Oleg Chertov; Aiko K. Shirakawa; Joshua M. Farber; David M. Segal; Joost J. Oppenheim; Larry W. Kwak

doi:10.1126/science.1075565

Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2

Arya Biragyn, Pier Adelchi Ruffini, Cynthia A. Leifer, Elena Klyushnenkova, Alexander Shakhov, Oleg Chertov, Aiko K. Shirakawa, Joshua M. Farber, David M. Segal, Joost J. Oppenheim, Larry W. Kwak

Lymphoma-Myeloma

Research output: Contribution to journal › Article › peer-review

839 Scopus citations

Abstract

β-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine β-defensin 2 (mDF2β) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2β may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.

Original language	English (US)
Pages (from-to)	1025-1029
Number of pages	5
Journal	Science
Volume	298
Issue number	5595
DOIs	https://doi.org/10.1126/science.1075565
State	Published - Nov 1 2002

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title = "Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2",

abstract = "β-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine β-defensin 2 (mDF2β) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2β may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.",

author = "Arya Biragyn and Ruffini, {Pier Adelchi} and Leifer, {Cynthia A.} and Elena Klyushnenkova and Alexander Shakhov and Oleg Chertov and Shirakawa, {Aiko K.} and Farber, {Joshua M.} and Segal, {David M.} and Oppenheim, {Joost J.} and Kwak, {Larry W.}",

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T1 - Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2

AU - Biragyn, Arya

AU - Ruffini, Pier Adelchi

AU - Leifer, Cynthia A.

AU - Klyushnenkova, Elena

AU - Shakhov, Alexander

AU - Chertov, Oleg

AU - Shirakawa, Aiko K.

AU - Farber, Joshua M.

AU - Segal, David M.

AU - Oppenheim, Joost J.

AU - Kwak, Larry W.

PY - 2002/11/1

Y1 - 2002/11/1

N2 - β-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine β-defensin 2 (mDF2β) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2β may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.

AB - β-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine β-defensin 2 (mDF2β) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2β may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.

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Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2

Abstract

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