Topical Fibronectin Improves Wound Healing of Irradiated Skin

Maxwell B. Johnson; Brandon Pang; Daniel J. Gardner; Solmaz Niknam-Benia; Vinaya Soundarajan; Athanasios Bramos; David P. Perrault; Kian Banks; Gene K. Lee; Regina Y. Baker; Gene H. Kim; Sunju Lee; Yang Chai; Mei Chen; Wei Li; Lawrence Kwong; Young Kwon Hong; Alex K. Wong

doi:10.1038/s41598-017-03614-y

Topical Fibronectin Improves Wound Healing of Irradiated Skin

Maxwell B. Johnson, Brandon Pang, Daniel J. Gardner, Solmaz Niknam-Benia, Vinaya Soundarajan, Athanasios Bramos, David P. Perrault, Kian Banks, Gene K. Lee, Regina Y. Baker, Gene H. Kim, Sunju Lee, Yang Chai, Mei Chen, Wei Li, Lawrence Kwong, Young Kwon Hong, Alex K. Wong

Translational Molecular Pathology

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds.

Original language	English (US)
Article number	3876
Journal	Scientific reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-03614-y
State	Published - Dec 1 2017

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Johnson, M. B., Pang, B., Gardner, D. J., Niknam-Benia, S., Soundarajan, V., Bramos, A., Perrault, D. P., Banks, K., Lee, G. K., Baker, R. Y., Kim, G. H., Lee, S., Chai, Y., Chen, M., Li, W., Kwong, L., Hong, Y. K., & Wong, A. K. (2017). Topical Fibronectin Improves Wound Healing of Irradiated Skin. Scientific reports, 7(1), Article 3876. https://doi.org/10.1038/s41598-017-03614-y

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title = "Topical Fibronectin Improves Wound Healing of Irradiated Skin",

abstract = "Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds.",

author = "Johnson, {Maxwell B.} and Brandon Pang and Gardner, {Daniel J.} and Solmaz Niknam-Benia and Vinaya Soundarajan and Athanasios Bramos and Perrault, {David P.} and Kian Banks and Lee, {Gene K.} and Baker, {Regina Y.} and Kim, {Gene H.} and Sunju Lee and Yang Chai and Mei Chen and Wei Li and Lawrence Kwong and Hong, {Young Kwon} and Wong, {Alex K.}",

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AU - Johnson, Maxwell B.

AU - Pang, Brandon

AU - Gardner, Daniel J.

AU - Niknam-Benia, Solmaz

AU - Soundarajan, Vinaya

AU - Bramos, Athanasios

AU - Perrault, David P.

AU - Banks, Kian

AU - Lee, Gene K.

AU - Baker, Regina Y.

AU - Kim, Gene H.

AU - Lee, Sunju

AU - Chai, Yang

AU - Chen, Mei

AU - Li, Wei

AU - Kwong, Lawrence

AU - Hong, Young Kwon

AU - Wong, Alex K.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds.

AB - Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds.

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Topical Fibronectin Improves Wound Healing of Irradiated Skin

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