Abstract
DNA topoisomerases are responsible for maintaining all the topological attributes of DNA by allowing the DNA strands to pass through each other during replication, transcription, and several other cellular transactions. Two distinct subfamilies of DNA topoisomerases enzymes solve various problems of disentangling DNA strands. But, the SNPs in these topoisomerase are associated with various disorders such as human laryngeal carcinoma, endometrial cancer, breast cancer, systemic scleroderma and neutropenia. This chapter discusses various disorders associated with SNPs in topoisomerases such as retinitis pigmentosa, systemic scleroderma, bloom’s syndrome and various risks associated with its pharmacogenetics. Special emphasis has been given on Topoisomerase Poisons as drugs and consequences of SNPs associated with topoisomerases based cancer therapy. The thorough SNP analysis is promising approach to identify possible genetic abnormalities of human chromosomal loci associated with disease prognosis, and specially the therapeutic response of various drugs. Knowledge of these specific SNPs pose a key to understand complex genetic mechanisms of various diseases, that may find a promising approach to cure diseases as per human’s genome specificity in the future.
| Original language | English (US) |
|---|---|
| Title of host publication | Topoisomerase Inhibitors |
| Subtitle of host publication | Classification, Mechanisms of Action and Adverse Effects |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 201-228 |
| Number of pages | 28 |
| ISBN (Electronic) | 9781536119152 |
| ISBN (Print) | 9781536118414 |
| State | Published - Jan 1 2017 |
| Externally published | Yes |
Keywords
- Bloom’s syndrome
- Retinitis pigmentosa
- SNPs
- Systemic scleroderma
- Topoisomerase
- Tumorigenesis
ASJC Scopus subject areas
- General Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)