TRAFs in RANK signaling

Bryant G Darnay; Arnaud Besse; Ann T. Poblenz; Betty Lamothe; Jörg J. Jacoby

doi:10.1007/978-0-387-70630-6_12

TRAFs in RANK signaling

Bryant G Darnay, Arnaud Besse, Ann T. Poblenz, Betty Lamothe, Jörg J. Jacoby

Experimental Therapeutics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

73 Scopus citations

Abstract

Members of the tumor necrosis factor (TNF) family govern many diverse physiological and cellular responses including cellular proliferation, differentiation, and apoptosis. Ligands of this family interact through a distinct set of specific receptors that lack enzymatic activity and therefore are dependent on the association of adaptor molecules. One receptor/ligand pair known as receptor activator of nuclear factor-kappa B (RANK) and RANK ligand (RANKL) regulates bone remodeling, mammary gland development, and lymph node organogenesis. RANK interacts with five members of the TNF receptor-associated factor (TRAF) family, of which TRAF6 is indispensable for its signaling capability. An accumulation of evidence from various research laboratories indicates TRAFs, but more importantly TRAF6, is the key to understanding how RANKL links cytoplasmic signaling to the nuclear transcriptional program.

Original language	English (US)
Title of host publication	TNF Receptor Associated Factors (TRAFs)
Publisher	Springer New York
Pages	152-159
Number of pages	8
ISBN (Print)	9780387706290
DOIs	https://doi.org/10.1007/978-0-387-70630-6_12
State	Published - 2007

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	597
ISSN (Print)	0065-2598

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-0-387-70630-6_12

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abstract = "Members of the tumor necrosis factor (TNF) family govern many diverse physiological and cellular responses including cellular proliferation, differentiation, and apoptosis. Ligands of this family interact through a distinct set of specific receptors that lack enzymatic activity and therefore are dependent on the association of adaptor molecules. One receptor/ligand pair known as receptor activator of nuclear factor-kappa B (RANK) and RANK ligand (RANKL) regulates bone remodeling, mammary gland development, and lymph node organogenesis. RANK interacts with five members of the TNF receptor-associated factor (TRAF) family, of which TRAF6 is indispensable for its signaling capability. An accumulation of evidence from various research laboratories indicates TRAFs, but more importantly TRAF6, is the key to understanding how RANKL links cytoplasmic signaling to the nuclear transcriptional program.",

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AU - Darnay, Bryant G

AU - Besse, Arnaud

AU - Poblenz, Ann T.

AU - Lamothe, Betty

AU - Jacoby, Jörg J.

PY - 2007

Y1 - 2007

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AB - Members of the tumor necrosis factor (TNF) family govern many diverse physiological and cellular responses including cellular proliferation, differentiation, and apoptosis. Ligands of this family interact through a distinct set of specific receptors that lack enzymatic activity and therefore are dependent on the association of adaptor molecules. One receptor/ligand pair known as receptor activator of nuclear factor-kappa B (RANK) and RANK ligand (RANKL) regulates bone remodeling, mammary gland development, and lymph node organogenesis. RANK interacts with five members of the TNF receptor-associated factor (TRAF) family, of which TRAF6 is indispensable for its signaling capability. An accumulation of evidence from various research laboratories indicates TRAFs, but more importantly TRAF6, is the key to understanding how RANKL links cytoplasmic signaling to the nuclear transcriptional program.

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TRAFs in RANK signaling

Abstract

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