TY - JOUR
T1 - Trans-cranial electrical stimulation attenuates abrupt morphine withdrawal in rats assayed by remote computerized quantification of multiple motor behavior indices
AU - Dougherty, Patrick M.
AU - Wei-Qiang Dong, Dong
AU - Faillace, Louis A.
AU - Dafny, Nachum
N1 - Funding Information:
This work was supported by a grant from the American Health Services Corporation.
PY - 1990/1/10
Y1 - 1990/1/10
N2 - The goal of the present study was to assess the effects of trans-cranial electrical stimulation on the behavioral signs of the abrupt withdrawal syndrome of rats. However, this goal also necessitated the introduction of an experimental model measuring animal behavior for prolonged periods of time using a computerized animal activity monitoring system to quantify spontaneous motor activities associated with abstinence behavior. Comparable withdrawal severity was obtained by both the activity monitoring system and investigator observation of motor signs of abstinence behavior. Moreover, using this system we demonstrate a time-dependent effect of electrical stimulation in reducing the severity of various indicies of motor hyperactivity associated with abrupt morphine withdrawal in rats.
AB - The goal of the present study was to assess the effects of trans-cranial electrical stimulation on the behavioral signs of the abrupt withdrawal syndrome of rats. However, this goal also necessitated the introduction of an experimental model measuring animal behavior for prolonged periods of time using a computerized animal activity monitoring system to quantify spontaneous motor activities associated with abstinence behavior. Comparable withdrawal severity was obtained by both the activity monitoring system and investigator observation of motor signs of abstinence behavior. Moreover, using this system we demonstrate a time-dependent effect of electrical stimulation in reducing the severity of various indicies of motor hyperactivity associated with abrupt morphine withdrawal in rats.
KW - Electrical stimulation
KW - Morphine
KW - Motor activity
KW - Withdrawal
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U2 - 10.1016/0014-2999(90)90229-Y
DO - 10.1016/0014-2999(90)90229-Y
M3 - Article
C2 - 2311653
AN - SCOPUS:0025092128
SN - 0014-2999
VL - 175
SP - 187
EP - 195
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -