Transcriptional control of Gad2

Zhizhong Z. Pan

doi:10.4161/trns.19511

Transcriptional control of Gad2

Zhizhong Z. Pan

Pain Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Gad2 encodes GAD65, which is present preferentially in presynaptic terminals for synthesis of GABA for vesicle release. Gad2 is a regulatory target of cell activities in various brain functions and in GABA perturbation-related neurological diseases. However, our understanding of how Gad2 is transcriptionally regulated and how Gad2 transcription responds to changing cell environment under these conditions is still limited. This review discusses recent advances in the regulatory mechanisms for Gad2 transcription and highlights the characteristics of TATA-less Gad2 promoters and regulation of Gad2 transcription by CREB and by activity-dependent epigenetic modification of the chromatin structure in regulatory elements of the Gad2 gene.

Original language	English (US)
Pages (from-to)	68-72
Number of pages	5
Journal	Transcription
Volume	3
Issue number	2
DOIs	https://doi.org/10.4161/trns.19511
State	Published - 2012

Keywords

GABA, GAD65, TATA-less promoters, cAMP-response element-binding protein (CREB), histone acetylation, chronic pain

ASJC Scopus subject areas

Biotechnology
Biochemistry
Genetics

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10.4161/trns.19511

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abstract = "Gad2 encodes GAD65, which is present preferentially in presynaptic terminals for synthesis of GABA for vesicle release. Gad2 is a regulatory target of cell activities in various brain functions and in GABA perturbation-related neurological diseases. However, our understanding of how Gad2 is transcriptionally regulated and how Gad2 transcription responds to changing cell environment under these conditions is still limited. This review discusses recent advances in the regulatory mechanisms for Gad2 transcription and highlights the characteristics of TATA-less Gad2 promoters and regulation of Gad2 transcription by CREB and by activity-dependent epigenetic modification of the chromatin structure in regulatory elements of the Gad2 gene.",

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Transcriptional control of Gad2

Abstract

Keywords

ASJC Scopus subject areas

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