Transcriptional mimicry by tumor-associated stroma

Hoon Kim; Roel G.W. Verhaak

doi:10.1038/ng.3255

Transcriptional mimicry by tumor-associated stroma

Hoon Kim, Roel G.W. Verhaak

Bioinformatics & Computational Biology

Research output: Contribution to journal › Short survey › peer-review

13 Scopus citations

Abstract

Recent molecular classification of colorectal cancer (CRC) has identified a poor-prognosis transcriptional subtype associated with mesenchymal traits. New studies used CRC transcriptomic data to show that tumor-associated stroma mimics the gene signature of epithelial-to-mesenchymal transition (EMT) and found no evidence for EMT of colorectal tumor cells.

Original language	English (US)
Pages (from-to)	307-309
Number of pages	3
Journal	Nature Genetics
Volume	47
Issue number	4
DOIs	https://doi.org/10.1038/ng.3255
State	Published - Apr 28 2015

ASJC Scopus subject areas

Genetics

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title = "Transcriptional mimicry by tumor-associated stroma",

abstract = "Recent molecular classification of colorectal cancer (CRC) has identified a poor-prognosis transcriptional subtype associated with mesenchymal traits. New studies used CRC transcriptomic data to show that tumor-associated stroma mimics the gene signature of epithelial-to-mesenchymal transition (EMT) and found no evidence for EMT of colorectal tumor cells.",

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AU - Kim, Hoon

AU - Verhaak, Roel G.W.

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N2 - Recent molecular classification of colorectal cancer (CRC) has identified a poor-prognosis transcriptional subtype associated with mesenchymal traits. New studies used CRC transcriptomic data to show that tumor-associated stroma mimics the gene signature of epithelial-to-mesenchymal transition (EMT) and found no evidence for EMT of colorectal tumor cells.

AB - Recent molecular classification of colorectal cancer (CRC) has identified a poor-prognosis transcriptional subtype associated with mesenchymal traits. New studies used CRC transcriptomic data to show that tumor-associated stroma mimics the gene signature of epithelial-to-mesenchymal transition (EMT) and found no evidence for EMT of colorectal tumor cells.

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Transcriptional mimicry by tumor-associated stroma

Abstract

ASJC Scopus subject areas

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