@article{4fcd7894bc5d41e99ca5868788c4b314,
title = "Transcriptional regulation of Th2 differentiation by inducible costimulator",
abstract = "Helper T (Th) cell differentiation is accompanied by complex transcriptional changes. Although costimulatory receptors are important in Th differentiation, the underlying mechanisms are poorly understood. Here we examine the transcriptional mechanisms by which ICOS regulates Th2 differentiation and selective IL-4 expression by effector T cells. We found impaired expression of c-Maf transcription factor functionally associated with the IL-4 defect in ICOS-/- cells. c-Maf expression in effector cells was regulated by IL-4 levels during Th differentiation. ICOS costimulation potentiated the T cell receptor (TcR)-mediated initial IL-4 production, possibly through the enhancement of NFATc1 expression. These data indicate that ICOS, by enhancing TcR signals at an early stage of T cell activation, regulates IL-4 transcription and T cell function in effector cells.",
author = "Nurieva, {Roza I.} and Julie Duong and Hiroko Kishikawa and Umberto Dianzani and Rojo, {Jose M.} and Ho, {I. Cheng} and Flavell, {Richard A.} and Chen Dong",
note = "Funding Information: The authors dedicate this work to the memory of Dr. Charles Janeway. We thank Dr. Laurie Glimcher for her generous help, support, and provision of key reagents, and Drs. Karen Makar and Hong Yu for their advice/help on the real-time PCR and retroviral transduction experiments, respectively. We are also grateful to Drs. Heon Park and Thang Nguyen, Eileen Yoshida, and Caroline Bishop for their critical reading of the manuscript and to the entire Dong lab for their help and discussion. This work is supported in part by a start-up fund from the Department of Immunology at the University of Washington and by grants from the National Institutes of Health (to C.D. and R.A.F.). R.A.F. is an investigator of the Howard Hughes Medical Institute and C.D. is a recipient of an Arthritis Investigator award of the Arthritis Foundation and a Basil O'Connor Starter Scholar award from March of Dimes Foundation.",
year = "2003",
month = jun,
day = "1",
doi = "10.1016/S1074-7613(03)00144-4",
language = "English (US)",
volume = "18",
pages = "801--811",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "6",
}