Abstract
The Tup1-Ssn6 complex from budding yeast is one of the best studied corepressors and has served as a model for the study of similar corepressor complexes in higher eukaryotes. Tup1-Ssn6 represses multiple subsets of genes when recruited to promoters by sequence-specific DNA binding repressors. Tup1-Ssn6 mediated repression involves interactions among the corepressor and hypoacetylated histones, histone deacetylases, and the RNA transcriptional machinery. Nucleosome positioning is also involved in repression of a subset of Tup1-Ssn6 regulated genes. These findings highlight the importance of chromatin modification states in Tup1-Ssn6 mediated repression. Here we review the multiple mechanisms involved in repression and discuss Tup1-Ssn6 homolog functions in higher organisms. We also present a model for how repression by Tup1-Ssn6 may be established.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 437-443 |
| Number of pages | 7 |
| Journal | Biochemistry and Cell Biology |
| Volume | 84 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 2006 |
Keywords
- -Ssn6
- Corepressor
- Histone deacetylases and chromatin
- Repression
- Transcription
- Tup
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology