Abstract
Carcinoid tumor of the prostate is extremely rare. Here we report a unique case of prostate cancer that underwent complete transformation from conventional adenocarcinoma to carcinoid-like tumor shortly after androgen-deprivation treatment (ADT). The patient was a 59-year-old man who presented with lower urinary tract symptoms. His biopsy specimen demonstrated a high-grade prostatic adenocarcinoma with mixed acinar and ductal features. After ADT for 6 months, the patient underwent radical prostatectomy. The post-ADT tumor showed monotonous neoplastic cells with fine granular chromatin forming rosette-like structures, resembling a carcinoid tumor. No residual conventional adenocarcinoma was present. On immunostain, the tumor cells were diffusely positive for synaptophysin and chromogranin and negative for prostate-specific antigen and prostein. Thus, the carcinoid-like tumor represented complete transformation from prostatic adenocarcinoma to well-differentiated neuroendocrine tumor after ADT. This unique case highlights the important role of ADT in neuroendocrine differentiation of prostate cancer.
Original language | English (US) |
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Pages (from-to) | 186-190 |
Number of pages | 5 |
Journal | Human Pathology |
Volume | 64 |
DOIs | |
State | Published - Jun 1 2017 |
Keywords
- Adenocarcinoma
- Carcinoid
- Hormonal treatment
- Neuroendocrine differentiation
- Prostate cancer
ASJC Scopus subject areas
- Pathology and Forensic Medicine