Transfusion-related acute lung injury (TRALI)

Adriana Maria Knopfelmacher

doi:10.1007/978-3-319-74588-6_108

Transfusion-related acute lung injury (TRALI)

Adriana Maria Knopfelmacher

Laboratory Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

TRALI is an adult respiratory distress syndrome occurring within 6 h of transfusion that presents with fever, cyanosis, dyspnea, and opacity of the pulmonary fields on frontal chest radiograph. TRALI has been described with all blood components, and its mechanism has been associated with donor HLA antibodies and some biologic response modifiers that trigger a leukocyte damage of the lung capillaries leading to leakage of fluid in the alveolar spaces. There is a 20% mortality as consequence of TRALI, and many patients require oxygen support and mechanical ventilation.

Original language	English (US)
Title of host publication	Oncologic Critical Care
Publisher	Springer International Publishing
Pages	1191-1196
Number of pages	6
ISBN (Electronic)	9783319745886
ISBN (Print)	9783319745879
DOIs	https://doi.org/10.1007/978-3-319-74588-6_108
State	Published - Oct 12 2019

Keywords

TRALI
Transfusion fatality

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-319-74588-6_108

Cite this

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AB - TRALI is an adult respiratory distress syndrome occurring within 6 h of transfusion that presents with fever, cyanosis, dyspnea, and opacity of the pulmonary fields on frontal chest radiograph. TRALI has been described with all blood components, and its mechanism has been associated with donor HLA antibodies and some biologic response modifiers that trigger a leukocyte damage of the lung capillaries leading to leakage of fluid in the alveolar spaces. There is a 20% mortality as consequence of TRALI, and many patients require oxygen support and mechanical ventilation.

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KW - Transfusion fatality

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PB - Springer International Publishing

ER -

Transfusion-related acute lung injury (TRALI)

Abstract

Keywords

ASJC Scopus subject areas

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