Transfusion therapy in children with sickle cell disease

Adlette Inati; Anthony G. Mansour; Toni Sabbouh; Ghid Amhez; Ahmad Hachem; Hussein A. Abbas

doi:10.1097/MPH.0000000000000645

Transfusion therapy in children with sickle cell disease

Adlette Inati, Anthony G. Mansour, Toni Sabbouh, Ghid Amhez, Ahmad Hachem, Hussein A. Abbas

Leukemia

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Hydroxyurea, blood transfusions, and hematopoietic stem cell transplantation represent the 3 disease-modifying therapies in children with sickle cell disease (SCD). Blood transfusions play an increasingly important role in both prevention and management of SCD complications in this age group. This review will focus on the indications of blood transfusion in children with SCD and modalities of its administration. It will also highlight the complications of this life-saving therapy and ways of optimizing transfusion to minimize its associated risks.

Original language	English (US)
Pages (from-to)	126-132
Number of pages	7
Journal	Journal of Pediatric Hematology/Oncology
Volume	39
Issue number	2
DOIs	https://doi.org/10.1097/MPH.0000000000000645
State	Published - 2017

Keywords

blood transfusion indications
iron overload
sickle cell disease

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/MPH.0000000000000645

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abstract = "Hydroxyurea, blood transfusions, and hematopoietic stem cell transplantation represent the 3 disease-modifying therapies in children with sickle cell disease (SCD). Blood transfusions play an increasingly important role in both prevention and management of SCD complications in this age group. This review will focus on the indications of blood transfusion in children with SCD and modalities of its administration. It will also highlight the complications of this life-saving therapy and ways of optimizing transfusion to minimize its associated risks.",

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AU - Inati, Adlette

AU - Mansour, Anthony G.

AU - Sabbouh, Toni

AU - Amhez, Ghid

AU - Hachem, Ahmad

AU - Abbas, Hussein A.

PY - 2017

Y1 - 2017

N2 - Hydroxyurea, blood transfusions, and hematopoietic stem cell transplantation represent the 3 disease-modifying therapies in children with sickle cell disease (SCD). Blood transfusions play an increasingly important role in both prevention and management of SCD complications in this age group. This review will focus on the indications of blood transfusion in children with SCD and modalities of its administration. It will also highlight the complications of this life-saving therapy and ways of optimizing transfusion to minimize its associated risks.

AB - Hydroxyurea, blood transfusions, and hematopoietic stem cell transplantation represent the 3 disease-modifying therapies in children with sickle cell disease (SCD). Blood transfusions play an increasingly important role in both prevention and management of SCD complications in this age group. This review will focus on the indications of blood transfusion in children with SCD and modalities of its administration. It will also highlight the complications of this life-saving therapy and ways of optimizing transfusion to minimize its associated risks.

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Transfusion therapy in children with sickle cell disease

Abstract

Keywords

ASJC Scopus subject areas

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