Translational genomics in cancer research: converting profiles into personalized cancer medicine

Lalit Patel; Brittany Parker; Da Yang; Wei Zhang

doi:10.7497/j.issn.2095-3941.2013.04.005

Translational genomics in cancer research: converting profiles into personalized cancer medicine

Lalit Patel, Brittany Parker, Da Yang, Wei Zhang

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole genomes. While the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis, it is also challenging our approach to managing patients suffering from this deadly disease. Specifically cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis, prognostication, and treatment selection. We review here recent work undertaken in cancer genomics with an emphasis on translation of genomic findings. Finally, we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.

Original language	English (US)
Pages (from-to)	214-220
Number of pages	7
Journal	Cancer Biology and Medicine
Volume	10
Issue number	4
DOIs	https://doi.org/10.7497/j.issn.2095-3941.2013.04.005
State	Published - Dec 2013

Keywords

Cancer
Genomics
Personalized medicine
Translation

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Translational genomics in cancer research: converting profiles into personalized cancer medicine",

abstract = "Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole genomes. While the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis, it is also challenging our approach to managing patients suffering from this deadly disease. Specifically cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis, prognostication, and treatment selection. We review here recent work undertaken in cancer genomics with an emphasis on translation of genomic findings. Finally, we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.",

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T2 - converting profiles into personalized cancer medicine

AU - Patel, Lalit

AU - Parker, Brittany

AU - Yang, Da

AU - Zhang, Wei

PY - 2013/12

Y1 - 2013/12

N2 - Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole genomes. While the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis, it is also challenging our approach to managing patients suffering from this deadly disease. Specifically cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis, prognostication, and treatment selection. We review here recent work undertaken in cancer genomics with an emphasis on translation of genomic findings. Finally, we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.

AB - Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole genomes. While the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis, it is also challenging our approach to managing patients suffering from this deadly disease. Specifically cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis, prognostication, and treatment selection. We review here recent work undertaken in cancer genomics with an emphasis on translation of genomic findings. Finally, we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.

KW - Cancer

KW - Genomics

KW - Personalized medicine

KW - Translation

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Translational genomics in cancer research: converting profiles into personalized cancer medicine

Abstract

Keywords

ASJC Scopus subject areas

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