Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue

Diana Bell; Yi Jue Zhao; Pulivarthi H. Rao; Randal S. Weber; Adel K. El-Naggar

doi:10.1007/s12105-007-0030-5

Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue

Diana Bell, Yi Jue Zhao, Pulivarthi H. Rao, Randal S. Weber, Adel K. El-Naggar

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed.

Original language	English (US)
Pages (from-to)	165-168
Number of pages	4
Journal	Head and Neck Pathology
Volume	1
Issue number	2
DOIs	https://doi.org/10.1007/s12105-007-0030-5
State	Published - 2007

Keywords

Adenoid cystic carcinoma
Comparative genomic hybridizations
Cytogenetic
Spectral karyotyping
Translocations

ASJC Scopus subject areas

Pathology and Forensic Medicine
Otorhinolaryngology
Oncology

Access to Document

10.1007/s12105-007-0030-5

Cite this

@article{5894408be64343c6a384104a616c054b,

title = "Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue",

abstract = "We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed.",

keywords = "Adenoid cystic carcinoma, Comparative genomic hybridizations, Cytogenetic, Spectral karyotyping, Translocations",

author = "Diana Bell and Zhao, {Yi Jue} and Rao, {Pulivarthi H.} and Weber, {Randal S.} and El-Naggar, {Adel K.}",

note = "Funding Information: Acknowledgments This work was supported in part by the Kenneth D. M{\"u}ller Professorship (AEN), National Cancer Institute Specialized Program of Research Excellence (SPORE) grant in head and neck cancer and the National Cancer Institute grant CA-16672.",

year = "2007",

doi = "10.1007/s12105-007-0030-5",

language = "English (US)",

volume = "1",

pages = "165--168",

journal = "Head and Neck Pathology",

issn = "1936-055X",

publisher = "Humana Press",

number = "2",

}

TY - JOUR

T1 - Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue

AU - Bell, Diana

AU - Zhao, Yi Jue

AU - Rao, Pulivarthi H.

AU - Weber, Randal S.

AU - El-Naggar, Adel K.

N1 - Funding Information: Acknowledgments This work was supported in part by the Kenneth D. Müller Professorship (AEN), National Cancer Institute Specialized Program of Research Excellence (SPORE) grant in head and neck cancer and the National Cancer Institute grant CA-16672.

PY - 2007

Y1 - 2007

N2 - We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed.

AB - We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed.

KW - Adenoid cystic carcinoma

KW - Comparative genomic hybridizations

KW - Cytogenetic

KW - Spectral karyotyping

KW - Translocations

UR - http://www.scopus.com/inward/record.url?scp=77749321145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77749321145&partnerID=8YFLogxK

U2 - 10.1007/s12105-007-0030-5

DO - 10.1007/s12105-007-0030-5

M3 - Article

C2 - 20614269

AN - SCOPUS:77749321145

SN - 1936-055X

VL - 1

SP - 165

EP - 168

JO - Head and Neck Pathology

JF - Head and Neck Pathology

IS - 2

ER -

Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this